SCOR Database

Short Chain Oxidoreductase Enzyme

SCOR (short chain oxidoreductase) proteins are a very large family of proteins. They are responsible for many processes vital to life on earth. There are two super families of SCOR proteins, defined by the fold each takes. The first is the aldoketo reductase super family, which forms a beta-barrel type fold. The rossmann fold defines the other family, which is an alternating Beta/alpha fold. The Rossmann superfamily is the larger of the two super families. PFAM has identified >23000 members that belong in this family. The members are responsible for the oxidation, reduction and epimierization of steroids, sugars, long chain fatty acids and xenobiotics from all species of life. Each member uses a cofactor NAD or NADP to help perform its action. Many families within The Rossmann family of SCOR proteins have been well defined, UDP-galactose, 17B HSD, FABG to name a few, but many are still undefined. Of the 23000 proteins in pfam, >9000 have the vague identifier "Short-chain". Collecting, sorting and filtering the proteins is an effective way to increase annotation and characterization of those proteins where this information is unavailable.

Values identified as sdr pFAM family and divided into groups by N-terminal motif

SwissProt Set of SCORs

Full Database Of SCORs

Old set