Short Chain OxidoReductase co-Evolution Database for substrate prediction
SCOR (short chain oxidoreductase) proteins are a very large family of proteins.
They are responsible for many processes vital to life on earth. There are two super families of
SCOR proteins, defined by the fold each takes. The first is the aldoketo reductase super family,
which forms a beta-barrel type fold. The Rossmann fold defines the other family, which is an
alternating Beta/alpha fold.
The Rossmann superfamily is the larger of the two super families. PFAM has identified >23000 members
that belong in this family. The members are responsible for the oxidation, reduction and epimierization
of steroids, sugars, long chain fatty acids and xenobiotics from all species of life. Each member uses a
cofactor NAD or NADP to help perform its action. Many families within The Rossmann family of SCOR proteins
have been well defined, UDP-galactose, 17B HSD, FABG to name a few, but many are still undefined.
Of the 23000 proteins in pfam, >9000 have the vague identifier "Short-chain". Collecting, sorting and
filtering the proteins is an effective way to increase annotation and characterization of those proteins
where this information is unavailable.
Search By Keyword
Search by Substrate Fingerprint
Where each value is a Amino acid that is found in the 3 loops in set positions (X1-X9). The positions are following NNAGxX1xX2, before X3xX4X5xxYxxxK and after PGX6xxxxX7X8xxX9. For a wild card search option leave the value as "*".
Browse By Substrate Fingerprint
Will generate a list of all substrate fingerprints in the database
Search by Amino Acid Properties of Substrate Fingerprint
This feature will select positions based on the physical properties of amino acids where Hydrophobic (Hydro): A, V, F, P, M, I, L, G; Charged: D, E, K, R; Polar: S, T, Y, H, C, N, Q, W. Any amino acid selected with the * value.
Browse By Properties of Substrate Fingerprint
Will generate a list of all substrate fingerprints in the database based on the properties of the fingerprint.
Browse all values of the database.
Interesting features of database
Total proteins in database: 40635 Total Use of Cofactor NAD: 11074 Total Use of Cofactor NADP: 29524 Total Use of Unknown Cofactor: 37
