2017

Clevinger, K. D., Mascarenhas, R., Catlin, D., Wu, R., Kelleher, N. L. Drake, E. J. Gulick, A. M., Liu, D., and Fast W. (2017) Substrate trapping in the siderophore tailoring enzyme PvdQ. ACS Chem Biol 12, 643-647.

Branchini, B. R., Southworth, T. L., Fontaine, D. M., Murtiashaw, M. H., McGurk, A., Talukder, M. H., Qureshi, R., Yeetil, D., Sundlov, J. A., and Gulick, A. M. (2017) Cloning of the orange light-producing luciferase from Photinus scintillans provides insight into bioluminescence color determination. Photochemistry and Photobiology 93, 479-485.

Gulick, A. M. (2017) Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens. Natural Products Reports, in press.

2016

Drake, E. J., Miller, B. M., Shi, C., Tarrasch, J. T., Sundlov, J. A., Allen, C. L., Skiniotis, G., Aldrich, C. C., and Gulick, A. M. (2016) Structures of two distinct conformations of holo-non-ribosomal peptide synthetases. Nature 539, 235-238.

Miller, B. M. and Gulick, A. M. (2016) Structural biology of nonribosomal peptide synthetases. Methods in Molecular Biology 1401, 3-29.

Drake, E. J. and Gulick, A. M. (2016) 1.2A Crystal structure of periplasmic aminotransferase PvdN from Pseudomonas aeruginosa Acta Cryst F 72, 403-408.

Richard, J. P., Amyes, T. L., Malabanan, M. M., Zhai, X., Kim, K. J., Reinhardt, C. J., Wierenga, R. K., Drake, E. J., and Gulick, A. M. (2016) Structure-function studies on hydrophobic residues that clamp a basic glutamate side-chain during catalysis by triosephosphate isomerase. Biochemistry 55, 3036-3047.

Bailey, D.C., Drake, E. J., Grant, T. D., and Gulick, A. M. (2016) Structural and functional characterization of aerobactin synthetase IucA from a hypervirulent pathotype of Klebsiella pneumoniae. Biochemistry 55, 3559-3570.

Meneely, K. M., Sundlov, J. A., Gulick, A. M., Moran, G. R., and Lamb, A. L. (2016) An open and shut case: The interaction of Magnesium with MST Enzymes. JACS 138, 9277-9293.

Miller, B. R., Drake, E. J., Shi, C., Aldrich, C. C., and Gulick, A. M. (2016) Structures of a nonribosomal peptide synthetase module bound to MbtH-like proteins support a highly dynamic domain architecture. JBC 291, 22559-22571.

Gulick, A. M. (2016) Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases. Curr. Opinion Chemical Biology 35, 89-96.

2015

Branchini, B. R., Behney, C. E., Southworth, T. L. Fontaine, D. M., Gulick, A. M., Vinyard, D. J., and Brudvig, G. W. (2015) Experimental support for a single electron transfer oxidation mechanism in firefly luciferase. JACS 137, 7592-7595.

Zhu, J., Lippa, G. M., Gulick, A. M., and Tipton, P. A. (2015) Examining reaction specificity in PvcB, a source of diversity in isonitrile containing natural products. Biochemistry 54, 2659-2669.

Kholodar, S. A., Allen, C. L., Gulick, A. M., and Murkin, A. S. (2015) The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces. JACS 137, 2748-2756.

Mitchell, C. A., Tucker, A. C., Escalante-Semerena, J. C., and Gulick, A. M. (2015) The Structure of S. lividans Acetoacetyl-CoA synthetase shows a novel interaction between the C-terminal extension and the N-terminal domain. Proteins 83, 575-581.

2014

Miller, B. R., Sundlov, J. A., Drake, E. J., Makin, T. A., and Gulick, A. M. (2014) Analysis of the linker region joining the adenylation and carrier protein domains of the modular non-ribosomal peptide synthetases. Proteins 82, 2691-2702.

Kholodar, S. A., Tombline, G., Liu, J., Tan, Z., Allen, C. L., Gulick, A. M., and Murkin, A. S. (2014) Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. Biochemistry 53, 3423-3431.

Wurst, J. M., Drake, E. J., Theriault, J. R., Jewett, I. T., VerPlank, L., Perez, J. R., Dandapani, S., Palmer, M., Moskowitz, S. M., Schreiber, S. L., Munoz, B., and Gulick, A. M. (2014) Identification of Inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chemical Biology 9, 1536-1544.

Allen, C. L. and Gulick, A. M. (2014) Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein. Acta Cryst D, 70, 1718-1725

Russo, T. A., Olson, R., MacDonald, U., Metzger, D., Maltese, L., Drake, E. J., and Gulick, A. M. (2014) Aerobactin mediates virulence and accounts for the increased siderophore production under iron limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae. Infection and Immunity 82, 2356-2367.

2013

Theriault, J. R., Wurst, J., Jewett, I., Verplank, L., Perez, J. R., Gulick, A. M., Drake, E. J., Palmer, M., Moskowitz, S., Dasgupta, N., Brannon, M. K., Dandapani, S., Munoz, B. and Schreiber, S. (2013) Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD):National Center for Biotechnology Information (US).

DeMonte, D., Drake, E. J., Lim, K. H., Gulick, A. M., and Park, S. (2013) Structure based engineering of streptavidin monomer with reduced biotin dissociation rate. Proteins 81, 1621-1633.

Sundlov, J. A. and Gulick, A. M. (2013) Structure determination of the functional domain interaction of a chimeric Non-Ribosomal Peptide Synthetase from a challenging crystal with non-crystallographic translational symmetry. Acta Cryst D 69, 1482-1492.

Neres, J. P., Engelhart, C. A., Drake, E. J., Wilson, D. J., Fu, P., Boshoff, H. I., Barry III, C. E., Gulick, A. M., and Aldrich, C. C. (2013) Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii. J. Med. Chem. 56, 2385-2405.

Tessier, M. B., Grant, O. C., Heimburg-Molinaro, J., Smith, D., Jadey, S., Gulick, A. M., Glushka, J., Deutscher, S. L., Rittenhouse-Olson, K., and Woods, R. J. (2013) Computational screening of the human TF-glycome provides a structural definition for the specificity of anti-tumor antibody JAA-F11. PLoS ONE 8(1), e54874.

Wilson, D. J., Shi, C., Teitelbaum, A. M., Gulick, A. M., and Aldrich, C. C. (2013) Characterization of AusA: A dimodular nonribosomal peptide synthetase responsible for production of aureusimine pyrazinones. Biochemistry 52, 926-937.

2012

Muppidi, A., Doi, K., Edwardraja, S., Drake, E. J., Gulick, A. M., Wang, H.-G., and Lin, Q. (2012) Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhbitors. JACS 134, 14734-14737.

Sundlov, J. A., Fontaine, D. M., Southworth, T. L., Branchini, B. R., and Gulick, A. M. (2012) Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism. Biochemistry 51, 6493-6495.

Mitchell, C. A., Shi, C., Aldrich, C. C., and Gulick, A. M. (2012) The structure of PA1221, a non-ribosomal peptide synthetase containing adenylation and peptidyl carrier protein domains. Biochemistry 51, 3241-3251.

Sundlov, J. A., Shi, C., Wilson, D. J., Aldrich, C. C., and Gulick, A. M. (2012) Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains. Chemistry & Biology 19, 188-198.

Reviews

Gulick, A. M. (2016) Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases. Curr. Opinion Chemical Biology 35, 89-96.

Miller, B. M. and Gulick, A. M. (2016) Structural biology of nonribosomal peptide synthetases. Methods in Molecular Biology 1401, 3-29.

Gulick, A. M. (2009) Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-Ribosomal Peptide Synthetases, and Firefly Luciferase. ACS Chemical Biology 4, 811-827.