Our work uses a variety of techniques to study protein structure and function. The main goal of our work is to figure out how enzymes use specific structures to catalyze interesting chemical reactions. We use a variety of techniques, including molecular and structural biology, as well as enzymology and other biophysical tools to understand protein structure and function. We have additionally developed novel chemical inhibitors that can be used to probe protein function in biological systems.
In particular, we are focused on Natural Product Biosynthesis and the fascinating proteins that bacteria use to make novel chemicals. Our lab is interested in understanding the enzymatic basis for these biosynthetic pathways, as well as the role that novel compounds play in bacterial growth and pathogenesis.
Andrew M. Gulick
Associate Professor, Department of Structural Biology
University at Buffalo
UB Lab Site
and Hauptman Woodward Institute
700 Ellicott St.
Buffalo, NY 14203-1102