NC_002645_HCoV-229E_inf-1_nsp12_ ------SFDNS-YLNRVRGSSA-ARLEPC-NGTDIDYCVRAFDVYN--KDASFIGKNLKS NC_005831_HCoV-NL63_AmsterdamI_n ------SVDIS-YLNRARGSSA-ARLEPC-NGTDIDKCVRAFDIYN--KNVSFLGKCLKM NC_002306_TGEV_PUR46-MAD_nsp12_1 ----SFTVDQS-YLNRVRGSSA-ARLEPC-NGTDPDHVSRAFDIYN--KDVACIGKFLKT NC_003436_PEDV_CV777_nsp12_12597 ------STDMA-YLNRVRGSSA-ARLEPC-NGTDTQHVYRAFDIYN--KDVACLGKFLKV DQ811787_PRCV_ISU-1_nsp12_12289. ----SSTVDQS-YLNRVRGSSA-ARLEPC-NGTDPDHVSRAFDIYN--KDVACIGKFLKT AY994055_FIPV_79-1146_nsp12_1238 ----GTTIDQS-YLNRVRGSSA-ARLEPC-NGTDPDHVSRAFDIYN--KDVACIGKFLKT NC_009657_BtCoV-G1_BtCoV/512/200 ------SVDSG-YLNRVRGSSA-ARLEPL-NGSDTHHVFRAFDVYN--RDVACISKFLKV EF203064_Bat-CoV-HKU2_HKU2/GD/43 ------STDQA-YLNRARGSSA-ARLEPC-NGTEPEHCVRAFDVYN--KDVACIGKFLKV NC_005147_HCoV-OC43_OC43_nsp12_1 ------SKDTN-FLNRVRGTSVDARLVPCASGLSTDVQLRAFDIYN--ASVAGIGLHLKV NC_006577_CoV-HKU1A_N1_nsp12_135 ------SKDLN-FLNRVRGTSVNARLVPCASGLSTDVQLRAFDICN--TNRAGIGLYYKV AY884001_CoV-HKU1B_N2_nsp12_1348 ------SKDLN-FLNRVRGTSVNARLVPCASGLSTDVQLRAFDICN--TNRAGIGLYYKV DQ339101_CoV-HKU1C_N5_nsp12_1342 ------SKDLN-FLNRVRGTSVNARLVPCASGLSTDVQLRAFDICN--TNRAGIGLYYKV NC_003045_BCoV_BCoV-ENT_nsp12_13 ------SKDTN-FLNRVRGTSVDARLVPCASGLSTDVQLRAFDICN--ASVAGIGLHLKV NC_001846_MHV_MHV-A59_nsp12_1357 ------SKDTN-FLNRVRGTSVNARLVPCASGLDTDVQLRAFDICN--ANRAGIGLYYKV NC_007732_PHEV_VW572_nsp12_13318 ------SKDTN-FLNRVRGTSVDARLVPCASGLSTDVQLRAFDICN--ASVAGIGLHLKV EF424621_AntelopeCoV_US/OH1/2003 ------SKDTN-FLNRVRGTSVDARLVPCASGLSTDVQLRAFDICN--ASVAGIGLHLKV EF424622_GiCoV_US/OH3-TC/2006_ns ------SKDTN-FLNRVRGTSVDARLVPCASGLSTDVQLRAFDICN--ASVAGIGLHLKV NC_004718_SARS-human_Tor2_nsp12_ ------SADASTFLNRVCGVSA-ARLTPCGTGTSTDVVYRAFDIYN--EKVAGFAKFLKT AY304488_SARS-civet_SZ16_nsp12_1 ------SADASTFLNRVCGVSA-ARLTPCGTGTSTDVVYRAFDIYN--EKVAGFAKFLKT NC_009694_SARS-bat_HKU3-1_nsp12_ ------SADASTFLNRVCGVSA-ARLTPCGTGTSTDVVYRAFDIYN--EKVAGFAKFLKT AY545919_SARS-badger_CFB/SZ/94/0 ------SADASTFLNRVCGVSA-ARLTPCGTGTSTDVVYRAFDIYN--EKVAGFAKFLKT NC_009019_Bat-CoV-HKU4_B04f ------SKDTN-FLNRVRGSSVNARLEPCSSGLTTDVVYRAFDICNFKARVAGIGKYYKT NC_009020_Bat-CoV-HKU5_LMH3f ------SKDSN-FLNRVRGSIVNARIEPCASGLTTDVVFRAFDICNYKAKVAGIGKYYKT NC_009021_Bat-CoV-HKU9_BF_005I ------ARDEC-FLNRVRGTSGVARLVPLGSGVQPDIVLRAFDICN--TKVAGFGLHLKN NC_001451_IBV_Beaudette_nsp12_12 SVAGASDFDKN-YLNRVRGSSE-ARLIPLASGCDPDVVKRAFDVCN--KESAGMFQNLKR AY646283_IBV-partridge_Partridge ADAGAPGFDKN-YLNRVRGSSE-ARLIPLANGCEPDVVKRAFDVCN--KESAGMFQNWKR AY641576_IBV-peafowl_Peafowl/GD/ SVAVASGFDKN-YLNRVRGSSE-ARLIPLANGCDPDVVKRAFDVCN--KESAGMFQNLKR * :***. * **: * .* ****: * : : * NC_002645_HCoV-229E_inf-1_nsp12_ NCVRFKNV--DK------DDAFYIVKRCIKSVMDHEQSMYNLLKGCNAVAKHDFFTWHEG NC_005831_HCoV-NL63_AmsterdamI_n NCVRFKNA--DL------KDGYFVIKRCTKSVMEHEQSMYNLLNFSGALAEHDFFTWKDG NC_002306_TGEV_PUR46-MAD_nsp12_1 NCSRFRNL--DK------HDAYYIVKRCTKTVMDHEQVCYNDLKDSGAVAEHDFFTYKEG NC_003436_PEDV_CV777_nsp12_12597 NCVRLKNL--DK------HDAFYVVKRCTKSAMEHEQSIYSRLEKCGAIAEHDFFTWKDG DQ811787_PRCV_ISU-1_nsp12_12289. NCSRFRNL--DK------HDAYYIVKRCTKTVMDHEQVCYNDLKDSGAVAEHDFFTYKEG AY994055_FIPV_79-1146_nsp12_1238 NCSRFRNL--DK------HDAYYVVKRCTKSVMDHEQVCYNDLKDSGVVAEHDFFLYKEG NC_009657_BtCoV-G1_BtCoV/512/200 NCVRLKNL--DK------HDAFWIVKKCTKSVMEHEQSIYNLISDCGAVAKHDFFTWKEG EF203064_Bat-CoV-HKU2_HKU2/GD/43 NCVRLKNL--DK------HDAFFVIKRCTKSVMEHEQSMYNKLSGSNALAVHDFFTWKDG NC_005147_HCoV-OC43_OC43_nsp12_1 NCCRFQRV--DENGDK--LDQFFVVKRTDLTIYNREMKCYERVKDCKFVAEHDFFTFDVE NC_006577_CoV-HKU1A_N1_nsp12_135 NCCRFQRI--DDDGNK--LDKFFVVKRTNLEVYNKEKTYYELTKSCGVVAEHDFFTFDID AY884001_CoV-HKU1B_N2_nsp12_1348 NCCRFQRI--DDDGNK--LDKFFVVKRTNLEVYNKEKTYYELTKSCGVVAEHDFFTFDID DQ339101_CoV-HKU1C_N5_nsp12_1342 NCCRFQRI--DDDGNK--LDKFFVVKRTNLEVYNKEKTYYELTKSCGVVAEHDFFTFDID NC_003045_BCoV_BCoV-ENT_nsp12_13 NCCRFQRV--DENGDK--LDQFFVVKRTDLTIYNREMECYERVKDCKFVAEHDFFTFDVE NC_001846_MHV_MHV-A59_nsp12_1357 NCCRFQRV--DEDGNK--LDKFFVVKRTNLEVYNKEKECYELTKECGVVAEHEFFTFDVE NC_007732_PHEV_VW572_nsp12_13318 NCCRFQRV--DENGDK--LDQFFVVKRTDLTIYNREMECYERVKDCKFVAEHDFFTFDVE EF424621_AntelopeCoV_US/OH1/2003 NCCRFQRV--DENGDK--LDQFFVVKRTDLTIYNREMECYERVKDCKFVAEHDFFTFDVE EF424622_GiCoV_US/OH3-TC/2006_ns NCCRFQRV--DENGDK--LDQFFVVKRTDLTIYNREMECYERVKDCKFVAEHDFFTFDVE NC_004718_SARS-human_Tor2_nsp12_ NCCRFQEK--DEEGNL--LDSYFVVKRHTMSNYQHEETIYNLVKDCPAVAVHDFFKFRVD AY304488_SARS-civet_SZ16_nsp12_1 NCCRFQEK--DEEGNL--LDSYFVVKRHTMSNYQHEETIYNLVKDCPAVAVHDFFKFRVD NC_009694_SARS-bat_HKU3-1_nsp12_ NCCRFQEK--DEEGNL--LDSYFVVKRHTMSNYQHEETIYNLIKECPAVAVHDFFKFRVD AY545919_SARS-badger_CFB/SZ/94/0 NCCRFQEK--DEEGNL--LDSYFVVKRHTMSNYQHEETIYNLVKDCPAVAVHDFFKFRVD NC_009019_Bat-CoV-HKU4_B04f NTCRFVQV--DDEGHK--LDSYFIVKRHTMSNYELEKRCYDLLKDCDAVAIHDFFIFDVD NC_009020_Bat-CoV-HKU5_LMH3f NTCRFVEV--DDEGHR--LDSFFVVKRHTMENYELEKRCYDLVKDCDAVAVHDFFIFDVD NC_009021_Bat-CoV-HKU9_BF_005I NCCRYQEL--DADGTQ--LDSYFVVKRHTESNYLLEQRCYEKLKDCGVVARHDFFKFNIE NC_001451_IBV_Beaudette_nsp12_12 NCARFQELRDTEDGNLEYLDSYFVVKQTTPSNYEHEKSCYEDLK-SEVTADHDFFVFN-- AY646283_IBV-partridge_Partridge NCARFQEVHDTEDGNLEYCDSYFVVKQTTPSNYEHEKSCYEDLK-SEVTASHDFFVFN-- AY641576_IBV-peafowl_Peafowl/GD/ NCARFQEVRDTEDGNLEYCDSYFVVKQTTPSNYEHEKACYEDLK-SEVTADHDFFVFN-- * * * ::::*. * *. . . * *:** : NC_002645_HCoV-229E_inf-1_nsp12_ RTIYGNVSRQDLTKYTMMDLCFALRNFDEKDCEVFKEILVLTGCCST---DYF-EMKNWF NC_005831_HCoV-NL63_AmsterdamI_n RVIYGNVSRHNLTKYTMMDLVYAMRNFDEQNCDVLKEVLVLTGCCDN---SYF-DSKGWY NC_002306_TGEV_PUR46-MAD_nsp12_1 RCEFGNVARRNLTKYTMMDLCYAIRNFDEKNCEVLKEILVTVGACTE---EFF-ENKDWF NC_003436_PEDV_CV777_nsp12_12597 RAIYGNVCRKDLTEYTMMDLCYALRNFDENNCDVLKSILIKVGACEE---SYF-NNKVWF DQ811787_PRCV_ISU-1_nsp12_12289. RCEFGNVARMNLTKYTMMDLCYAIRNFDEKNCEVLKEILVTVGACTE---EFF-ENKDWF AY994055_FIPV_79-1146_nsp12_1238 RCEFGNVARKDLTKYTMMDLCYAIRNFDEKNCEVLKEILVTLGACNE---SFF-ENKDWF NC_009657_BtCoV-G1_BtCoV/512/200 RSVYGNVCRQDLTEYTMMDLCYALRNFDENNCETLKKILVVVGACDE---SYF-DNKLWF EF203064_Bat-CoV-HKU2_HKU2/GD/43 RSIYGNVCRQDLSKYTMMDLCYALRNFDERNCETLKEILVLTGCCDQ---SYF-DNKVWY NC_005147_HCoV-OC43_OC43_nsp12_1 GSRVPHIVRKDLTKYTMLDLCYALRHFDRNDCMLLCDILSIYAGCEQ---SYF-TKKDWY NC_006577_CoV-HKU1A_N1_nsp12_135 GSRVPHIVRRNLSKYTMLDLCYALRHFDRNDCSILCEILCEYADCKE---SYF-SKKDWY AY884001_CoV-HKU1B_N2_nsp12_1348 GSRVPHIVRKNLSKYTMLDLCYALRHFDCNDCSVLCEILCEYADCKE---SYF-SKKDWY DQ339101_CoV-HKU1C_N5_nsp12_1342 GSRVPHIVRRNLSKYTMLDLCYALRHFDRNDCSILCEILCEYADCKE---SYF-SKKDWY NC_003045_BCoV_BCoV-ENT_nsp12_13 GSRVPHIVRKDLTKYTMLDLCYALRHFDRNDCMLLCDILSIYAGCEQ---SYF-TKKDWY NC_001846_MHV_MHV-A59_nsp12_1357 GSRVPHIVRKDLSKFTMLDLCYALRHFDRNDCSTLKEILLTYAECEE---SYF-QKKDWY NC_007732_PHEV_VW572_nsp12_13318 GSRVPHIVRKDLTKYTMLDLCYALRHFDRNDCMLLCDILSIYAGCEQ---SYF-TKKDWY EF424621_AntelopeCoV_US/OH1/2003 GSRVPHIVRKDLTKYTMLDLCYALRHFDRNDCMLLCDILSIYAGCEQ---SYF-TKKDWY EF424622_GiCoV_US/OH3-TC/2006_ns GSRVPHIVRKDLTKYTMLDLCYALRHFDRNDCMLLCDILSIYAGCEQ---SYF-TKKDWY NC_004718_SARS-human_Tor2_nsp12_ GDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDD---DYF-NKKDWY AY304488_SARS-civet_SZ16_nsp12_1 GDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDD---DYF-NKKDWY NC_009694_SARS-bat_HKU3-1_nsp12_ GDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDD---NYF-NKKDWY AY545919_SARS-badger_CFB/SZ/94/0 GDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDD---DYF-NKKDWY NC_009019_Bat-CoV-HKU4_B04f KTKTPHIVRQSLTEYTMMDLVYALRHFDQNNCEVLKSILVKYGCCEQ---SYF-DNKLWF NC_009020_Bat-CoV-HKU5_LMH3f KVKTPHIVRQRLTEYTMMDLVYALRHFDQNNCEVLKSILVKYGCCDA---SYF-DNKLWF NC_009021_Bat-CoV-HKU9_BF_005I GVMTPHVSRERLTKYTMADLVYSLRHFDNNNCDTLKEILVLRGCCTA---DYF-DRKDWY NC_001451_IBV_Beaudette_nsp12_12 KNIY-NISRQRLTKYTMMDFCYALRHFDPKDCEVLKEILVTYGCIEDYHPKWFEENKDWY AY646283_IBV-partridge_Partridge KNIY-NISRQRLTKYTMMDFCYALRHFDPKDCEVLKEILVTYGCIDDYHPKWFEENKDWY AY641576_IBV-peafowl_Peafowl/GD/ KNIY-NISRQRLTKYTMMDFCYALRHFDPKDCEVLKEILVTYGCIEDYHPKWFEENKDWY :: * *:::** *: :::*:** :* : .:* .:* * *: NC_002645_HCoV-229E_inf-1_nsp12_ DPIENEDIHRVYAALGKVVANAMLKCVAFCDEMVLKGVVGVLTLDNQDLNGNFYDFGDFV NC_005831_HCoV-NL63_AmsterdamI_n DPVENEDIHRVYASLGKIVARAMLKCVALCDAMVAKGVVGVLTLDNQDLNGNFYDFGDFV NC_002306_TGEV_PUR46-MAD_nsp12_1 DPVENEAIHEVYAKLGPIVANAMLKCVAFCDAIVEKGYIGVITLDNQDLNGNFYDFGDFV NC_003436_PEDV_CV777_nsp12_12597 DPVENEDIHRVYALLGTIVARAMLKCVKFCDAMVEQGIVGVVTLDNQDLNGDFYDFGDFT DQ811787_PRCV_ISU-1_nsp12_12289. DPVENEAIHEVYAKLGPIVANAMLKCVAFCDAIVEKGYIGVITLDNQDLNGNFYDFGDFV AY994055_FIPV_79-1146_nsp12_1238 DPVENEAIHEVYARLGPIVANAMLKCVAFCDAIVEKGYIGIITLDNQDLNGNFYDFGDFV NC_009657_BtCoV-G1_BtCoV/512/200 DPVENEDVHRVYAKLGTIVARAMLKCVKYCDAMVEQGIVGVITLDNQDLNGDFYDFGDFV EF203064_Bat-CoV-HKU2_HKU2/GD/43 DPVENEDLHRVYALLGQRVANAMLKCVKLCDEMVTKGVVGVLTLDNQDLNGNFYDFGDFV NC_005147_HCoV-OC43_OC43_nsp12_1 DFVENPDIINVYKKLGPIFNRALVSATEFADKLVEVGLVGVLTLDNQDLNGKWYDFGDYV NC_006577_CoV-HKU1A_N1_nsp12_135 DFVENPDIINIYKKLGPIFNRALLNTVIFADTLVEVGLVGVLTLDNQDLYGQWYDFGDFI AY884001_CoV-HKU1B_N2_nsp12_1348 DFVENPDIINIYKKLGPIFNRALLNTVSFADTLVKVGLVGVLTLDNQDLYGQWYDFGDFI DQ339101_CoV-HKU1C_N5_nsp12_1342 DFVENPDIINIYKKLGPIFNRALLNTVIFADTLVEVGLVGVLTLDNQDLYGQWYDFGDFI NC_003045_BCoV_BCoV-ENT_nsp12_13 DFVENPDIINVYKKLGPIFNRALVSATEFADKLVEVGLVGILTLDNQDLNGKWYDFGDYV NC_001846_MHV_MHV-A59_nsp12_1357 DFVENPDIINVYKKLGPIFNRALLNTAKFADALVEAGLVGVLTLDNQDLYGQWYDFGDFV NC_007732_PHEV_VW572_nsp12_13318 DFVENPDIINLYKKLGPILNRALVSATEFADKLVEVGLVGVLTLDNQDLNGKWYDFGDYV EF424621_AntelopeCoV_US/OH1/2003 DFVENPDIINVYKKLGPIFNRALVSATEFADKLVEVGLVGILTLDNQDLNGKWYDFGDYV EF424622_GiCoV_US/OH3-TC/2006_ns DFVENPDIINVYKKLGPIFNRALVSATEFADKLVEVGLVGILTLDNQDLNGKWYDFGDYV NC_004718_SARS-human_Tor2_nsp12_ DFVENPDILRVYANLGERVRQSLLKTVQFCDAMRDAGIVGVLTLDNQDLNGNWYDFGDFV AY304488_SARS-civet_SZ16_nsp12_1 DFVENPDILRVYANLGERVRQSLLKTVQFCDAMRDAGIVGVLTLDNQDLNGNWYDFGDFV NC_009694_SARS-bat_HKU3-1_nsp12_ DFVENPDVLRVYANLGERVRRALLKTVQFCDAMRDAGIVGVLTLDNQDLNGNWYDFGDFV AY545919_SARS-badger_CFB/SZ/94/0 DFVENPDILRVYANLGERVRQSLLKTVQFCDAMRDAGIVGVLTLDNQDLNGNWYDFGDFV NC_009019_Bat-CoV-HKU4_B04f DFVENPSVIGVYHKLGERIRQAMLNTVKMCDHMVKSGLVGVLTLDNQDLNGKWYDFGDFV NC_009020_Bat-CoV-HKU5_LMH3f DFVENPNVISVYHKLGERIRQAVLNTVKFCDQMVKSGLVGVLTLDNQDLNGKWYDFGDFV NC_009021_Bat-CoV-HKU9_BF_005I DPVENPDIIRVYHNLGETVRKAVLSAVKMADSMVEQGLIGVLTLDNQDLNGQWYDFGDFI NC_001451_IBV_Beaudette_nsp12_12 DPIENSKYYVMLAKMGPIVRRALLNAIEFGNLMVEKGYVGVITLDNQDLNGKFYDFGDFQ AY646283_IBV-partridge_Partridge DSIENPKYYAMLAKMGPIVRRALLNAVEFGNLMVEKGYVGVVTLDNQDLNGKFYDFGDFQ AY641576_IBV-peafowl_Peafowl/GD/ DPIENPKYYAMLAKMGPIVRRALLNAIEFGNLMVEKGYVGVITLDNQDLNGKFYDFGDFQ * :** : :* . .:::. : : * :*::******* *.:*****: NC_002645_HCoV-229E_inf-1_nsp12_ LCPPGMGIPYCTSYYSYMMPVMGMTNCLASECFMKSDIFGQDFKTFDLLKYDFTEHKEVL NC_005831_HCoV-NL63_AmsterdamI_n VSLPNMGVPCCTSYYSYMMPIMGLTNCLASECFVKSDIFGSDFKTFDLLKYDFTEHKENL NC_002306_TGEV_PUR46-MAD_nsp12_1 KTAPGFGCACVTSYYSYMMPLMGMTSCLESENFVKSDIYGSDYKQYDLLAYDFTEHKEYL NC_003436_PEDV_CV777_nsp12_12597 CSIKGMGVPICTSYYSYMMPVMGMTNCLASECFVKSDIFGEDFKSYDLLEYDFTEHKTAL DQ811787_PRCV_ISU-1_nsp12_12289. KTAPGFGCACVTSYYSYMMPLMGMTSCLESENFVKSDIYGSDYKQYDLLAYDFTEHKDYL AY994055_FIPV_79-1146_nsp12_1238 KTTPGFGCACVTSYYSYMMPLMGMTSCLESENFVKSDIYGADYKQYDLLAYDFTDHKEKL NC_009657_BtCoV-G1_BtCoV/512/200 TSVKGMGVPICTSYYSYMMPVMGMTNCLASECFIKSDIFGEDFRTFDLLAYDFTEHKVNL EF203064_Bat-CoV-HKU2_HKU2/GD/43 DVMPGMGIPCCTSYYSYMMPIMTMTNCLACECFMKSDIFGSDFKTYDLLEYDFTDHKVKL NC_005147_HCoV-OC43_OC43_nsp12_1 IAAPGCGVAIADSYYSYIMPMLTMCHALDCELYVNNA-----YRLFDLVQYDFTDYKLEL NC_006577_CoV-HKU1A_N1_nsp12_135 QTAPGFGVAVADSYYSYMMPMLTMCHVLDCELFVNDS-----YRQFDLVQYDFTDYKLEL AY884001_CoV-HKU1B_N2_nsp12_1348 QTAPGFGVAVADSYYSYMMPMLTMCHVLDCELFVNDS-----YRQFDLVQYDFTDYKLEL DQ339101_CoV-HKU1C_N5_nsp12_1342 QTAPGFGVAVADSYYSYMMPMLTMCHVLDCELFVNDS-----YRQFDLVQYDFTDYKLEL NC_003045_BCoV_BCoV-ENT_nsp12_13 IAAPGCGVAIADSYYSYMMPMLTMCHALDCELYVNNA-----YRLFDLVQYDFTDYKLEL NC_001846_MHV_MHV-A59_nsp12_1357 KTVPGCGVAVADSYYSYMMPMLTMCHALDSELFVNGT-----YREFDLVQYDFTDFKLEL NC_007732_PHEV_VW572_nsp12_13318 IAAPGCGVAIADSYYSYMMPMLTMCHALDCELYVNNA-----YRLFDLVQYDFTDYKLEL EF424621_AntelopeCoV_US/OH1/2003 IAAPGCGVAIADSYYSYMMPMLTMCHALDCELYVNNA-----YRLFDLVQYDFTDYKLEL EF424622_GiCoV_US/OH3-TC/2006_ns IAAPGCGVAIADSYYSYMMPMLTMCHALDCELYVNNA-----YRLFDLVQYDFTDYKLEL NC_004718_SARS-human_Tor2_nsp12_ QVAPGCGVPIVDSYYSLLMPILTLTRALAAESHMDAD-LAKPLIKWDLLKYDFTEERLCL AY304488_SARS-civet_SZ16_nsp12_1 QVAPGCGVPIVDSYYSLLMPILTLTRALAAESHMDAD-LAKPLIKWDLLKYDFTEERLCL NC_009694_SARS-bat_HKU3-1_nsp12_ QVAPGCGVPIVDSYYSLLMPILTLTKALAAESHMDAD-LAKPLVKWDLLKYDFTEERLCL AY545919_SARS-badger_CFB/SZ/94/0 QVAPGCGVPIVDSYYSLLMPILTLTRALAAESHMDAD-LAKPLIKWDLLKYDFTEERLCL NC_009019_Bat-CoV-HKU4_B04f ITQPGAGVAIVDSYYSYLMPVLSMTNCLAAETHKDCD-FNKPLIEWPLLEYDYTDYKIGL NC_009020_Bat-CoV-HKU5_LMH3f ITQPGAGVAIVDSYYSYLMPVLSMTNCLAAETHRDCD-LTKPLIEWPLLEYDYTDYKIGL NC_009021_Bat-CoV-HKU9_BF_005I EGPAGAGVAVMDTYYSLAMPVYTMTNMLAAECHVDGD-FSKPKRVWDICKYDYTQFKYSL NC_001451_IBV_Beaudette_nsp12_12 KTAPGAGVPVFDTYYSYMMPIIAMTDALAPERYFEYD-VHKGYKSYDLLKYDYTEEKQEL AY646283_IBV-partridge_Partridge KTALGAGVPVFDTYYSYMMPIIAMTDALASERYFEYD-VHKGYKSYDLLKYDYTEEKQEL AY641576_IBV-peafowl_Peafowl/GD/ KTAPGAGVPVFDTYYSYMMPIIAMTDALAPERYFEYD-VHKGYKSYDLLKYDYTEEKQEL . * . :*** **: : * * . . : : **:*: . * NC_002645_HCoV-229E_inf-1_nsp12_ FNKYFKYWGQDYHPDCVDCHDEMCILHCSNFNTLFATTIPNTAFGPLCRKVFIDGVPVVA NC_005831_HCoV-NL63_AmsterdamI_n FNKYFKHWSFDYHPNCSDCYDDMCVIHCANFNTLFATTIPGTAFGPLCRKVFIDGVPLVT NC_002306_TGEV_PUR46-MAD_nsp12_1 FQKYFKYWDRTYHPNCSDCTSDECIIHCANFNTLFSMTIPMTAFGPLVRKVHIDGVPVVV NC_003436_PEDV_CV777_nsp12_12597 FNKYFKYWGLQYHPNCVDCSDEQCIVHCANFNTLFSTTIPITAFGPLCRKCWIDGVPLVT DQ811787_PRCV_ISU-1_nsp12_12289. FQKYFKYWDRTYHPNCSDCTSDECIIHCANFNTLFSMTVPMTAFGPLVRKVHIDGVPVVV AY994055_FIPV_79-1146_nsp12_1238 FHKYFKHWDRTYHPNCSDCTSDECIIHCANFNTLFSMTIPSTAFGPLVRKVHIDGVPVVV NC_009657_BtCoV-G1_BtCoV/512/200 FNKYFKHWGQTYHPNCEDCHDESCIVHCANFNTLFATTIPITAFGPLCRKCWIDGVPLVT EF203064_Bat-CoV-HKU2_HKU2/GD/43 FDKYFKYWGQDYHPNCSDCYDDMCLLHCSNFNTLFSTTIPNTAFGPLCRKVFVDGVPLIA NC_005147_HCoV-OC43_OC43_nsp12_1 FNKYFKHWSMPYHPNTVDCQDDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV NC_006577_CoV-HKU1A_N1_nsp12_135 FNKYFKYWGMKYHPNTVDCDNDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV AY884001_CoV-HKU1B_N2_nsp12_1348 FNKYFKYWGMKYHPNTVDCDNDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV DQ339101_CoV-HKU1C_N5_nsp12_1342 FNKYFKYWGMKYHPNTVDCDNDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV NC_003045_BCoV_BCoV-ENT_nsp12_13 FNKYFKHWSMPYHPNTVDCQDDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV NC_001846_MHV_MHV-A59_nsp12_1357 FTKYFKHWSMTYHPNTCECEDDRCIIHCANFNILFSMVLPKTCFGPLVRQIFVDGVPFVV NC_007732_PHEV_VW572_nsp12_13318 FNKYFKHWSMPYHPNTVDCQDDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV EF424621_AntelopeCoV_US/OH1/2003 FNKYFKHWSMPYHPNTVDCQDDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV EF424622_GiCoV_US/OH3-TC/2006_ns FNKYFKHWSMPYHPNTVDCQDDRCIIHCANFNILFSMVLPNTCFGPLVRQIFVDGVPFVV NC_004718_SARS-human_Tor2_nsp12_ FDRYFKYWDQTYHPNCINCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVV AY304488_SARS-civet_SZ16_nsp12_1 FDRYFKYWDQTYHPNCINCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVV NC_009694_SARS-bat_HKU3-1_nsp12_ FDRYFKYWDQTYHPNCINCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVV AY545919_SARS-badger_CFB/SZ/94/0 FDRYFKYWDQTYHPNCINCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVV NC_009019_Bat-CoV-HKU4_B04f FNKYFKYWDQTYHPNCVNCSDDRCILHCANFNVLFSMVLPNTSFGPIVRKIFVDGVPFIV NC_009020_Bat-CoV-HKU5_LMH3f FEKYFKXWDQQYHPNCVNCTDDRCVLHCANFNVLFSMTLPGTSFGPIVRKIFVDGVPFVI NC_009021_Bat-CoV-HKU9_BF_005I FSKYFKYWDMQYHPNCVACADDRCILHCANFNILFSMVLPNTSFGPLVQKIYVDGVPFVV NC_001451_IBV_Beaudette_nsp12_12 FQKYFKYWDQEYHPNCRDCSDDRCLIHCANFNILFSTLIPQTSFGNLCRKVFVDGVPFIA AY646283_IBV-partridge_Partridge FQKYFKYWDQEYHPNCCDCYDDRCLIHCANFNILFSTLIPQTSFGNLCRKVFVDGVPFIA AY641576_IBV-peafowl_Peafowl/GD/ FQKYFKYWDQEYHPNCRDCSDDRCLIHCANFNILFSTLVPQTSFGNLCRKVFVGGVPFIA * .*** *. ***: * .: *::**:*** **: .* *.** : .: :.***.: NC_002645_HCoV-229E_inf-1_nsp12_ TAGYHFKQLGLVWNKDVNTHSTRLTITELLQFVTDPTLIVASSPALVDKRTVCFSVAALS NC_005831_HCoV-NL63_AmsterdamI_n TAGYHFKQLGLVWNKDVNTHSVRLTITELLQFVTDPSLIIASSPALVDQRTICFSVAALS NC_002306_TGEV_PUR46-MAD_nsp12_1 TAGYHFKQLGIVWNLDVKLDTMKLSMTDLLRFVTDPTLLVASSPALLDQRTVCFSIAALS NC_003436_PEDV_CV777_nsp12_12597 TAGYHFKQLGIVWNNDLNLHSSRLSINELLQFCSDPALLIASSPALVDQRTVCFSVAALG DQ811787_PRCV_ISU-1_nsp12_12289. TAGYHFKQLGIVWNLDVKLDTMKLSMTDLLRFVTDPTLLVASSPALLDQRTVCFSIAALS AY994055_FIPV_79-1146_nsp12_1238 TAGYHFKQLGIVWNLDVKLDTMKLSMTDLLRFVTDPTLLVASSPALLDQRTVCFSIAALS NC_009657_BtCoV-G1_BtCoV/512/200 TAGYHFKQLGIVWNKDLNLHSSRLTINELLQFCADPSLLIASSPALVDKRTVCFSVAALG EF203064_Bat-CoV-HKU2_HKU2/GD/43 TAGYHFKQLGLVWNKDINTHNSRLSMTDLLQFVTDPGLLIASSPALVDQRTVCFSIAALS NC_005147_HCoV-OC43_OC43_nsp12_1 SIGYHYKELGIVMNMDVDTHRYRLSLKDLLLYAADPALHVASASALYDLRTCCFSVAAIT NC_006577_CoV-HKU1A_N1_nsp12_135 SIGYHYKELGVVMNLDVDTHRYRLSLKDLLLYAADPAMHVASASALLDLRTCCFSVAAIT AY884001_CoV-HKU1B_N2_nsp12_1348 SIGYHYKELGVVMNLDVDTHRYRLSLKDLLLYAADPAMHVASASALLDLRTCCFSVAAIT DQ339101_CoV-HKU1C_N5_nsp12_1342 SIGYHYKELGVVMNLDVDTHRYRLSLKDLLLYAADPAMHVASASALLDLRTCCFSVAAIT NC_003045_BCoV_BCoV-ENT_nsp12_13 SIGYHYKELGIVMNMDVDTHRYRLSLKDLLLYAADPALHVASASALYDLRTCCFSVAAIT NC_001846_MHV_MHV-A59_nsp12_1357 SIGYHYKELGVVMNMDVDTHRYRLSLKDLLLYAADPALHVASASALLDLRTCCFSVAAIT NC_007732_PHEV_VW572_nsp12_13318 SIGYHYKELGIVMNMDVDTHRYRLSLKDLLLYAADPALHVASASALYDLRTCCFSVAAIT EF424621_AntelopeCoV_US/OH1/2003 SIGYHYKELGIVMNMDVDTHRYRLSLKDLLLYAADPALHVASASALYDLRTCCFSVAAIT EF424622_GiCoV_US/OH3-TC/2006_ns SIGYHYKELGIVMNMDVDTHRYRLSLKDLLLYAADPALHVASASALYDLRTCCFSVAAIT NC_004718_SARS-human_Tor2_nsp12_ STGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALT AY304488_SARS-civet_SZ16_nsp12_1 STGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALT NC_009694_SARS-bat_HKU3-1_nsp12_ STGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALT AY545919_SARS-badger_CFB/SZ/94/0 STGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALT NC_009019_Bat-CoV-HKU4_B04f SCGYHYKELGLVMNMDFNIHRHRLALKELMMYAADPAMHIASASALWDLRTPCFSVAALT NC_009020_Bat-CoV-HKU5_LMH3f SCGYHYKELGLVMNMDVSLHRHRLSLKELMMYAADPAMHIASASALWDLRTPCFSVAALT NC_009021_Bat-CoV-HKU9_BF_005I STGYHYRELGVVMNQDIRQHAQRLSLRELLVYAADPAMHVAASNALADKRTVCMSVAAMT NC_001451_IBV_Beaudette_nsp12_12 TCGYHSKELGVIMNQDNTMSFSKMGLSQLMQFVGDPALLVGTSNNLVDLRTSCFSVCALT AY646283_IBV-partridge_Partridge TCGYHSKELGVIMNQDNTMSFSKMGLSQLMKFVGDPSLLVGTSNNLVDLRTSCFSVCALT AY641576_IBV-peafowl_Peafowl/GD/ TCGYHSKELGVIMNQDNTMSFSKMGLSQLMQFVGDPALLVGTSNKLVDLRTSCFSVCALA : *** .:**:: * * .: : :*: : ** : .:. * * ** *:*:.*: NC_002645_HCoV-229E_inf-1_nsp12_ TGLTSQTVKPGHFNKEFYDFLRSQGFFDEGSELTLKHFFFTQKGDAAIKDFDYYRYNRPT NC_005831_HCoV-NL63_AmsterdamI_n TGLTNQVVKPGHFNEEFYNFLRLRGFFDEGSELTLKHFFFAQNGDAAVKDFDFYRYNKPT NC_002306_TGEV_PUR46-MAD_nsp12_1 TGITYQTVKPGHFNKDFYDFITERGFFEEGSELTLKHFFFAQGGEAAMTDFNYYRYNRVT NC_003436_PEDV_CV777_nsp12_12597 TGMTNQTVKPGHFNKEFYDFLLEQGFFSEGSELTLKHFFFAQKVDAAVKDFDYYRYNRPT DQ811787_PRCV_ISU-1_nsp12_12289. TGITYQTVKPGHFNKDFYDFITERGFFEEGSELTLKHFFFAQGGEAAMTDFNYYRYNRVT AY994055_FIPV_79-1146_nsp12_1238 TGVTYQTVKPGHFNKDFYDFITERGFFEEGSELTLKHFFFAQGGEAAMTDFNYYRYNRVT NC_009657_BtCoV-G1_BtCoV/512/200 TGMTNQTVKPGHFNREFYDFLRSQGFFEEGSELTLKHFFFAQKGDAAVRDFDYYRYNRTT EF203064_Bat-CoV-HKU2_HKU2/GD/43 TGITHQTVKPGHFNKEFYDYLLSQGFFDEGSELTLKHFFFAQKGDAAVADFDYYRYNKPT NC_005147_HCoV-OC43_OC43_nsp12_1 SGVKFQTVKPGNFNQDFYDFVLSKGLLKEGSSVDLKHFFFTQDGNAAITDYNYYKYNLPT NC_006577_CoV-HKU1A_N1_nsp12_135 SGIKFQTVKPGNFNQDFYEFVKSKGLFKEGSTVDLKHFFFTQDGNAAITDYNYYKYNLPT AY884001_CoV-HKU1B_N2_nsp12_1348 SGIKFQTVKPGNFNQDFYEFVKSKGLFKEGSTVDLKHFFFTQDGNAAITDYNYYKYNLPT DQ339101_CoV-HKU1C_N5_nsp12_1342 SGIKFQTVKPGNFNQDFYEFVKSKGLFKEGSTVDLKHFFFTQDGNAAITDYNYYKYNLPT NC_003045_BCoV_BCoV-ENT_nsp12_13 SGVKFQTVKPGNFNQDFYDFILSKGLLKEGSSVDLKHFFFTQDGNAAITDYNYYKYNLPT NC_001846_MHV_MHV-A59_nsp12_1357 SGVKFQTVKPGNFNQDFYEFILSKGLLKEGSSVDLKHFFFTQDGNAAITDYNYYKYNLPT NC_007732_PHEV_VW572_nsp12_13318 SGVKFQTVKPGNFNQDFYDFILSKGMLKEGSSVDLKHFFFTQDGNAAITDYNYYKYNLPT EF424621_AntelopeCoV_US/OH1/2003 SGVKFQTVKPGNFNQDFYDFILSKGLLKEGSSVDLKHFFFTQDGNAAITDYNYYKYNLPT EF424622_GiCoV_US/OH3-TC/2006_ns SGVKFQTVKPGNFNQDFYDFILSKGLLKEGSSVDLKHFFFTQDGNAAITDYNYYKYNLPT NC_004718_SARS-human_Tor2_nsp12_ NNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPT AY304488_SARS-civet_SZ16_nsp12_1 NNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPT NC_009694_SARS-bat_HKU3-1_nsp12_ NNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPT AY545919_SARS-badger_CFB/SZ/94/0 NNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPT NC_009019_Bat-CoV-HKU4_B04f TGLTFQTVRPGNFNKDFYDFVVSRGFFKEGSSVTLKHFFFAQDGHAAITDYSYYAYNLPT NC_009020_Bat-CoV-HKU5_LMH3f TGLTFQTVRPGNFNKDFYDFVVSKGFFKEGSSVTLRHFFFAQDGHAAITDYSYYAYNLPT NC_009021_Bat-CoV-HKU9_BF_005I TGVTFQTVKPGQFNEDFYNFAVKCGFFKEGSTISFKHFFYAQDGNAAISDYDYYRYNLPT NC_001451_IBV_Beaudette_nsp12_12 SGITHQTVKPGHFNKDFYDFAEKAGMFKEGSSIPLKHFFYPQTGNAAINDYDYYRYNRPT AY646283_IBV-partridge_Partridge SGITHQTVKPGHFNKDFYDFAEKAGMFKEGSSIPLKHFFYPQTGNAAINDYDYYRYNRPT AY641576_IBV-peafowl_Peafowl/GD/ SGITHQTVKPGHFNKDFYDFAEKAGMFKEGSSIPLKHFFYPQTGNAAINDYDYYRYNRPT ..: *.*.**:** :**:: *::.*** : :.***:.* **: *:.:* ** * NC_002645_HCoV-229E_inf-1_nsp12_ MLDIGQARVAYQVAARYFDCYEGGCITSREVVVTNLNKSAGWPLNKFGKAGLYYESISYE NC_005831_HCoV-NL63_AmsterdamI_n ILDICQARVTYKIVSRYFDIYEGGCIKACEVVVTNLNKSAGWPLNKFGKASLYYESISYE NC_002306_TGEV_PUR46-MAD_nsp12_1 VLDICQAQFVYKIVGKYFECYDGGCINAREVVVTNYDKSAGYPLNKFGKARLYYETLSYE NC_003436_PEDV_CV777_nsp12_12597 VLDICQARVVYQIVQRYFDIYEGGCITAKEVVVTNLNKSAGYPLNKFGKAGLYYESLSYE DQ811787_PRCV_ISU-1_nsp12_12289. VLDICQAQFVYKIVGKYFECYDGGCISAREVVVTNYDKSAGYPLNKFGKARLYYETLSYE AY994055_FIPV_79-1146_nsp12_1238 VLDICQAQFVYKIVGKYFECYDGGCINAREVVVTNYDKSAGYPLNKFGKARLYYETLSYE NC_009657_BtCoV-G1_BtCoV/512/200 VLDICQARVVYQIVQCYFGMYEGGCITAKEVIVNNLNKSAGYPFNKFGKAGLYYDSLSYE EF203064_Bat-CoV-HKU2_HKU2/GD/43 MLDICMARFTYKVVQRYFECYDGGCITAREVVVTNLDKSAGYPLNRFGKARLFYETFSYE NC_005147_HCoV-OC43_OC43_nsp12_1 MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE NC_006577_CoV-HKU1A_N1_nsp12_135 MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE AY884001_CoV-HKU1B_N2_nsp12_1348 MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE DQ339101_CoV-HKU1C_N5_nsp12_1342 MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE NC_003045_BCoV_BCoV-ENT_nsp12_13 MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE NC_001846_MHV_MHV-A59_nsp12_1357 MVDIKQLLFVLEVVNKYFEIYEGGCIPATQVIVNNYDKSAGYPFNKFGKARLYYEALSFE NC_007732_PHEV_VW572_nsp12_13318 MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE EF424621_AntelopeCoV_US/OH1/2003 MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE EF424622_GiCoV_US/OH3-TC/2006_ns MVDIKQLLFVLEVVYKYFEIYDGGCIPASQVIVNNYDKSAGYPFNKFGKARLYYEALSFE NC_004718_SARS-human_Tor2_nsp12_ MCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYE AY304488_SARS-civet_SZ16_nsp12_1 MCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYE NC_009694_SARS-bat_HKU3-1_nsp12_ MCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYE AY545919_SARS-badger_CFB/SZ/94/0 MCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYE NC_009019_Bat-CoV-HKU4_B04f MVDIKQMLFCMEVVDKYFDIYDGGCLNASEVIVNNLDKSAGHPFNKFGKARVYYESMSYQ NC_009020_Bat-CoV-HKU5_LMH3f MCDIKQMLFCMEVVDRYFEIYDGGCLNASEVIVNNLDKSAGHPFNKFGKARVYYESLSYQ NC_009021_Bat-CoV-HKU9_BF_005I MCDIKQLLFSLEVVDKYFDCYDGGCLQASQVVVANYDKSAGFPFNKFGKARLYYESLSYA NC_001451_IBV_Beaudette_nsp12_12 MFDICQLLFCLEVTSKYFECYEGGCIPASQVVVNNLDKSAGYPFNKFGKARLYYE-MSLE AY646283_IBV-partridge_Partridge MFDIRQLLFCLEVASKYFECYEGGCIPASQVVVTNLDKSAGYPFNKFGKARLYYE-MSLE AY641576_IBV-peafowl_Peafowl/GD/ MFDIRQLLFCLEVTSKYFECYEGGCIPASQVVVNNLDKSAGYPFNKFGKARLYYE-MSLE : ** . ::. ** *:***: : :*:* * :**** *:*.:*** ::*: :* NC_002645_HCoV-229E_inf-1_nsp12_ EQDAIFSLTKRNILPTMTQLNLKYAISGKERARTVGGVSLLATMTTRQFHQKCLKSIVAT NC_005831_HCoV-NL63_AmsterdamI_n EQDALFALTKRNVLPTMTQLNLKYAISGKERARTVGGVSLLSTMTTRQYHQKHLKSIVNT NC_002306_TGEV_PUR46-MAD_nsp12_1 EQDALFALTKRNVLPTMTQMNLKYAISGKARARTVGGVSLLSTMTTRQYHQKHLKSIAAT NC_003436_PEDV_CV777_nsp12_12597 EQDELYAYTKRNILPTMTQLNLKYAISGKERARTVGGVSLLSTMTTRQYHQKHLKSIVNT DQ811787_PRCV_ISU-1_nsp12_12289. EQDALFALTKRNVLPTMTQMNLKYAISGKARARTVGGVSLLSTMTTRQYHQKHLKSIAAT AY994055_FIPV_79-1146_nsp12_1238 EQDALFALTKRNVLPTMTQMNLKYAISGKARARTVGGVSLLSTMTTRQYHQKHLKSIAAT NC_009657_BtCoV-G1_BtCoV/512/200 EQDDLYAYTKRNIIPTMTQLNLKYAISGKDRARTVGGVSLLSTMTTRQYHQKHLKSIVNT EF203064_Bat-CoV-HKU2_HKU2/GD/43 EQDALYAMTKRNILPTMTQLNLKYSISGKARARTVGGVSLLATMTTRQFHQKHLKSIVNT NC_005147_HCoV-OC43_OC43_nsp12_1 EQDEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT NC_006577_CoV-HKU1A_N1_nsp12_135 EQNEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT AY884001_CoV-HKU1B_N2_nsp12_1348 EQNEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT DQ339101_CoV-HKU1C_N5_nsp12_1342 EQNEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT NC_003045_BCoV_BCoV-ENT_nsp12_13 EQDEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT NC_001846_MHV_MHV-A59_nsp12_1357 EQDEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT NC_007732_PHEV_VW572_nsp12_13318 EQDEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT EF424621_AntelopeCoV_US/OH1/2003 EQDEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT EF424622_GiCoV_US/OH3-TC/2006_ns EQDEIYAYTKRNVLPTLTQMNLKYAISAKNRARTVAGVSILSTMTGRMFHQKCLKSIAAT NC_004718_SARS-human_Tor2_nsp12_ DQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAAT AY304488_SARS-civet_SZ16_nsp12_1 DQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAAT NC_009694_SARS-bat_HKU3-1_nsp12_ DQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAAT AY545919_SARS-badger_CFB/SZ/94/0 DQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAAT NC_009019_Bat-CoV-HKU4_B04f EQDELFAVTKRNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQYHQKMLKSMAAT NC_009020_Bat-CoV-HKU5_LMH3f EQDELFAMTKRNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQYHQKMLKSMAAT NC_009021_Bat-CoV-HKU9_BF_005I DQDELFAYTKRNVLPTITQMNLKYAISAKNRARTVAGVSIASTMTNRQFHQKMLKSIAAA NC_001451_IBV_Beaudette_nsp12_12 EQDQLFEITKKNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQFHQKILKSIVNT AY646283_IBV-partridge_Partridge EQDQLFESTKKNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQFHQKVLKSIVNT AY641576_IBV-peafowl_Peafowl/GD/ EQDQLFESTKKNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQSHQKILKSIVNT :*: :: **.*::**:**:****:**.* *****.***: :*** * *** ***:. : NC_002645_HCoV-229E_inf-1_nsp12_ RNATVVIGTTKFYGGWDNMLKNLMADVDDPKLMGWDYPKCDRAMPSMIRMLSAMILGSKH NC_005831_HCoV-NL63_AmsterdamI_n RNATVVIGTTKFYGGWNNMLRTLIDGVENPMLMGWDYPKCDRALPNMIRMISAMVLGSKH NC_002306_TGEV_PUR46-MAD_nsp12_1 RNATVVIGSTKFYGGWDNMLKNLMRDVDNGCLMGWDYPKCDRALPNMIRMASAMILGSKH NC_003436_PEDV_CV777_nsp12_12597 RGASVVIGTTKFYGGWDNMLKNLIDGVENPCLMGWDYPKCDRALPNMIRMISAMILGSKH DQ811787_PRCV_ISU-1_nsp12_12289. RNATVVIGSTKFYGGWDNMLKNLMRDVDNGCLMGWDYPKCDRALPNMIRMASAMILGSKH AY994055_FIPV_79-1146_nsp12_1238 RNATVVIGSTKFYGGWDNMLKNLMRDVDNGCLMGWDYPKCDRALPNMIRMASAMILGSKH NC_009657_BtCoV-G1_BtCoV/512/200 RGASVVIGTTKFYGGWDNMLKTLIKDVENPHLMGWDYPKCDRALPNMIRMISAMILGSKH EF203064_Bat-CoV-HKU2_HKU2/GD/43 RNAPVVIGTTKFYGGWDNMLKNLMNDVDNGALMGWDYPKCDRAMPSMIRMLAAMVLGSKH NC_005147_HCoV-OC43_OC43_nsp12_1 RGVPVVIGTTKFYGGWDDMLRRLIKDVDNPVLMGWDYPKCDRAMPNLLRIVSSLVLARKH NC_006577_CoV-HKU1A_N1_nsp12_135 RGVPVVIGTTKFYGGWDDMLRHLIKDVDNPVLMGWDYPKCDRAMPNILRIVSSLVLARKH AY884001_CoV-HKU1B_N2_nsp12_1348 RGVPVVIGTTKFYGGWDDMLRHLIKDVDNPVLMGWDYPKCDRAMPNILRIVSSLVLARKH DQ339101_CoV-HKU1C_N5_nsp12_1342 RGVPVVIGTTKFYGGWDDMLRHLIKDVDNPVLMGWDYPKCDRAMPNILRIVSSLVLARKH NC_003045_BCoV_BCoV-ENT_nsp12_13 RGVPVVIGTTKFYGGWDDMLRRLIKDVDNPVLMGWDYPKCDRAMPNILRIVSSLVLARKH NC_001846_MHV_MHV-A59_nsp12_1357 RGVPVVIGTTKFYGGWDDMLRRLIKDVDSPVLMGWDYPKCDRAMPNILRIVSSLVLARKH NC_007732_PHEV_VW572_nsp12_13318 RGVPVVIGTTKFYGGWDDMLRRLIKDVDNPVLMGWDYPKCDRAMPNILRIVSSLVLARKH EF424621_AntelopeCoV_US/OH1/2003 RGVPVVIGTTKFYGGWDDMLRRLIKDVDNPVLMGWDYPKCDRAMPNILRIVSSLVLARKH EF424622_GiCoV_US/OH3-TC/2006_ns RGVPVVIGTTKFYGGWDDMLRRLIKDVDNPVLMGWDYPKCDRAMPNILRIVSSLVLARKH NC_004718_SARS-human_Tor2_nsp12_ RGATVVIGTSKFYGGWHNMLKTVYSDVETPHLMGWDYPKCDRAMPNMLRIMASLVLARKH AY304488_SARS-civet_SZ16_nsp12_1 RGATVVIGTSKFYGGWHNMLKTVYSDVETPHLMGWDYPKCDRAMPNMLRIMASLVLARKH NC_009694_SARS-bat_HKU3-1_nsp12_ RGATVVIGTSKFYGGWHNMLKTVYSDVESPHLMGWDYPKCDRAMPNMLRIMASLILARKH AY545919_SARS-badger_CFB/SZ/94/0 RGATVVIGTSKFYGGWHNMLKTVYSDVETPHLMGWDYPKCDRAMPNMLRIMASLVLARKH NC_009019_Bat-CoV-HKU4_B04f RGATCVIGTTKFYGGWDFMLKTLYKDVESPHLMGWDYPKCDRAMPNMCRILASLILARKH NC_009020_Bat-CoV-HKU5_LMH3f RGSTCVIGTTKFYGGWDFMLKTLYKDVDNPHLMGWDYPKCDRAMPNMCRIFASLILARKH NC_009021_Bat-CoV-HKU9_BF_005I RGASVVIGTTKFYGGWNRMLRTLCEGVENPHLMGWDYPKCDRAMPNLLRIFASLILARKH NC_001451_IBV_Beaudette_nsp12_12 RNASVVIGTTKFYGGWDNMLRNLIQGVEDPILMGWDYPKCDRAMPNLLRIAASLVLARKH AY646283_IBV-partridge_Partridge RNASVVIGTTKFYGGWDNMLRNLIQGVEDPMLMGWDYPKCDRAMPNLLRIAASLVLARKH AY641576_IBV-peafowl_Peafowl/GD/ RNAPVVIGTTKFYGGWDNMLRNLIQGVEDPILMGWDYPKCDRAMPNLLRIAASLVLARKH *. . ***::****** **. : .*: ************:*.: *: ::::*. ** NC_002645_HCoV-229E_inf-1_nsp12_ VTCCTASDKFYRLSNELAQVLTEVVYSNGGFYFKPGGTTSGDATTAYANSVFNIFQAVSS NC_005831_HCoV-NL63_AmsterdamI_n VNCCTATDRFYRLGNELAQVLTEVVYSNGGFYFKPGGTTSGDASTAYANSIFNIFQAVSS NC_002306_TGEV_PUR46-MAD_nsp12_1 VGCCTHNDRFYRLSNELAQVLTEVVHCTGGFYFKPGGTTSGDGTTAYANSAFNIFQAVSA NC_003436_PEDV_CV777_nsp12_12597 TTCCSSTDRFFRLCNELAQVLTEVVYSNGGFYLKPGGTTSGDATTAYANSVFNIFQAVSA DQ811787_PRCV_ISU-1_nsp12_12289. VGCCTHNDRFYRLSNELAQVLTEVVHCTGGFYFKPGGTTSGDGTTAYANSAFNIFQAVSA AY994055_FIPV_79-1146_nsp12_1238 VGCCTHSDRFYRLSNELAQVLTEVVHCTGGFYFKPGGTTSGDGTTAYANSAFNIFQAVSA NC_009657_BtCoV-G1_BtCoV/512/200 VNCCSSSDRYYRLCNELAQVLTEMVYSNGGFYVKPGGTTSGDATTAYANSVFNIFQATSA EF203064_Bat-CoV-HKU2_HKU2/GD/43 VTCCTDSDRFYRLSNELAQVLNEVVHSNGGFYVKPGGTTSGDATTAYANSVFNIFQAVSS NC_005147_HCoV-OC43_OC43_nsp12_1 ETCCSQSDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVSA NC_006577_CoV-HKU1A_N1_nsp12_135 EFCCSHGDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVTA AY884001_CoV-HKU1B_N2_nsp12_1348 EFCCSHGDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVTA DQ339101_CoV-HKU1C_N5_nsp12_1342 EFCCSHGDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVTA NC_003045_BCoV_BCoV-ENT_nsp12_13 EACCSQSDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVSA NC_001846_MHV_MHV-A59_nsp12_1357 DSCCSHTDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVSA NC_007732_PHEV_VW572_nsp12_13318 EACCSQSDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVSA EF424621_AntelopeCoV_US/OH1/2003 EACCSQSDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVSA EF424622_GiCoV_US/OH3-TC/2006_ns EACCSQSDRFYRLANECAQVLSEIVMCGGCYYVKPGGTSSGDATTAFANSVFNICQAVSA NC_004718_SARS-human_Tor2_nsp12_ NTCCNLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTA AY304488_SARS-civet_SZ16_nsp12_1 NTCCNLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTA NC_009694_SARS-bat_HKU3-1_nsp12_ STCCNLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTA AY545919_SARS-badger_CFB/SZ/94/0 NTCCNLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTA NC_009019_Bat-CoV-HKU4_B04f STCCTNSDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDATTAYANSVFNILQATTA NC_009020_Bat-CoV-HKU5_LMH3f STCCTNTDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDATTAYANSVFNILQATTA NC_009021_Bat-CoV-HKU9_BF_005I ATCCNASERFYRLANECAQVLSEMVLCGGGFYVKPGGTSSGDSTTAYANSVFNICQAVSA NC_001451_IBV_Beaudette_nsp12_12 TNCCSWSERIYRLYNECAQVLSETVLATGGIYVKPGGTSSGDATTAYANSVFNIIQATSA AY646283_IBV-partridge_Partridge TNCCTWSERIYRLYNECAQVLSETVLATGGIYVKPGGTSSGDATTAYANSVFNIIQATSA AY641576_IBV-peafowl_Peafowl/GD/ TNCCTWPERIYRLYNECAQVLSETVLATGGIYVKPGGTSSGDATTAYANSVFNIIQATSA **. . :** ** ****.* * . * *.*****:***.:**:*** *** **.:: NC_002645_HCoV-229E_inf-1_nsp12_ NINCVLSVNSSNCNNFNVKKLQRQLYDNCYRNSNVDESFVDDFYGYLQKHFSMMILSDDS NC_005831_HCoV-NL63_AmsterdamI_n NINRLLSVPSDSCNNVNVRDLQRRLYDNCYRLTSVEESFIDDYYGYLRKHFSMMILSDDG NC_002306_TGEV_PUR46-MAD_nsp12_1 NVNKLLGVDSNACNNVTVKSIQRKIYDNCYRSSSIDEEFVVEYFSYLRKHFSMMILSDDG NC_003436_PEDV_CV777_nsp12_12597 NVNKLLSVDSNVCHNLEVKQLQRKLYECCYRSTIVDDQFVVEYYGYLRKHFSMMILSDDG DQ811787_PRCV_ISU-1_nsp12_12289. NVNKLLGVDSNACNNVTVKSIQRKVYDNCYRSSSIDEEFVVEYFSYLRKHFSMMILSDDG AY994055_FIPV_79-1146_nsp12_1238 NVNKLLGVDSNACNNVTVKSIQRKIYDNCYRSSSIDEEFVVEYFSYLRKHFSMMILSDDG NC_009657_BtCoV-G1_BtCoV/512/200 NVNRLLSVDSNTCNNIEVKQLQRKLYDCCYRSSSVDQSFVEEYFGYLRKHFSMMILSDDG EF203064_Bat-CoV-HKU2_HKU2/GD/43 NINRLLSVDSNVCNNLYVKKLQRSIYDNCYRSSAVDDNVVTDFYNYLKKHFSMMILSDDG NC_005147_HCoV-OC43_OC43_nsp12_1 NVCALMSCNGNKIEDLSIRALQKRLYSHVYRSDKVDSTFVTEYYEFLNKHFSMMILSDDG NC_006577_CoV-HKU1A_N1_nsp12_135 NVCSLMACNGHKIEDLSIRNLQKRLYSNVYRTDYVDYTFVNEYYEFLCKHFSMMILSDDG AY884001_CoV-HKU1B_N2_nsp12_1348 NVCSLMACNGHKIEDLSIRNLQKRLYSNVYRTDYVDYTFVNEYYEFLCKHFSMMILSDDG DQ339101_CoV-HKU1C_N5_nsp12_1342 NVCSLMACNGHKIEDLSIRNLQKRLYSNVYRTDYVDYTFVNEYYEFLCKHFSMMILSDDG NC_003045_BCoV_BCoV-ENT_nsp12_13 NVCALMSCNGNKIEDLSIRALQKRLYSHVYRSDMVDSTFVTEYYEFLNKHFSMMILSDDG NC_001846_MHV_MHV-A59_nsp12_1357 NVCSLMACNGHKIEDLSIRELQKRLYSNVYRADHVDPAFVSEYYEFLNKHFSMMILSDDG NC_007732_PHEV_VW572_nsp12_13318 NVCSLMSCNGNKIEDLSIRALQKRLYSHVYRSDMVDSTFVTEYYEFLNKHFSMMILSDDG EF424621_AntelopeCoV_US/OH1/2003 NVCALMSCNGNKIEDLSIRALQKRLYSHVYRSDMVDTTFVTEYYEFLNKHFSMMILSDDG EF424622_GiCoV_US/OH3-TC/2006_ns NVCALMSCNGNKIEDLSIRALQKRLYSHVYRSDMVDTTFVTEYYEFLNKHFSMMILSDDG NC_004718_SARS-human_Tor2_nsp12_ NVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRKHFSMMILSDDA AY304488_SARS-civet_SZ16_nsp12_1 NVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRKHFSMMILSDDA NC_009694_SARS-bat_HKU3-1_nsp12_ NVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRKHFSMMILSDDA AY545919_SARS-badger_CFB/SZ/94/0 NVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRKHFSMMILSDDA NC_009019_Bat-CoV-HKU4_B04f NVSALMSANGNTIIDREIKDMQFDLYINVYRKVVPDPKFVDKYYAFLNKHFSMMILSDDG NC_009020_Bat-CoV-HKU5_LMH3f NVSALMGANGNTIVDEEVKDMQFELYVNVYRKSQPDPKFVDRYYAFLNKHFSMMILSDDG NC_009021_Bat-CoV-HKU9_BF_005I NLNTFLSIDGNKIYTTYVQELQRRLYLGIYRSNTVDNELVLDYYNYLRKHFSMMILSDDG NC_001451_IBV_Beaudette_nsp12_12 NVARLLSVITRDIVYDNIKSLQYELYQQVYRRVNFDPAFVEKFYSYLCKNFSLMILSDDG AY646283_IBV-partridge_Partridge NVARLLSVITRDIVYDDIKSLQYELYQQVYRRVNFDPAFVEKFYSYMCKNFSLMILSDDG AY641576_IBV-peafowl_Peafowl/GD/ NVARLLSVITRDIVYDDIKDLQYELYQQVYRRVNFDSAFVEKFYSYLCKNFSLMILSDDG *: .:. :. :* :* ** : .: :: :: *:**:******. NC_002645_HCoV-229E_inf-1_nsp12_ VVCYNKTYAGLGYIADISAFKATLYYQNGVFMSTAKCWTEEDLSIGPHEFCSQHTMQIVD NC_005831_HCoV-NL63_AmsterdamI_n VVCYNKDYAELGYIADISAFKATLYYQNNVFMSTSKCWVEEDLTKGPHEFCSQHTMQIVD NC_002306_TGEV_PUR46-MAD_nsp12_1 VVCYNKDYADLGYVADINAFKATLYYQNNVFMSTSKCWVEPDLSVGPHEFCSQHTLQIVG NC_003436_PEDV_CV777_nsp12_12597 VVCYNNDYASLGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINKGPHEFCSQHTMQIVD DQ811787_PRCV_ISU-1_nsp12_12289. VVCYNKDYADLGYVADINAFKATLYYQNNVFMSTSKCWVEPDLSVGPHEFCSQHTLQIVG AY994055_FIPV_79-1146_nsp12_1238 VVCYNKDYADLGYVADINAFKATLYYQNNVFMSTSKCWVEPDLSVGPHEFCSQHTLQIVG NC_009657_BtCoV-G1_BtCoV/512/200 VVCYNSEYAALGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINKGPHEFCSQHTMQIVD EF203064_Bat-CoV-HKU2_HKU2/GD/43 VVCYNKEYAALGYVGDISAFKATLYYQNNVFMSTAKCWVEEDLSVGPHEFCSQHTMQIVD NC_005147_HCoV-OC43_OC43_nsp12_1 VVCYNSDYASKGYIANISAFQQVLYYQNNVFMSESKCWVEHDINNGPHEFCSQHTMLVKM NC_006577_CoV-HKU1A_N1_nsp12_135 VVCYNSDYASKGYIANISVFQQVLYYQNNVFMSESKCWVENDITNGPHEFCSQHTMLVKI AY884001_CoV-HKU1B_N2_nsp12_1348 VVCYNSDYASKGYIANISVFQQVLYYQNNVFMSESKCWVENDITNGPHEFCSQHTMLVKI DQ339101_CoV-HKU1C_N5_nsp12_1342 VVCYNSDYANKGYIANISAFQQVLYYQNNVFMSESKCWVENDITNGPHEFCSQHTMLVKI NC_003045_BCoV_BCoV-ENT_nsp12_13 VVCYNSDYASKGYIANISAFQQVLYYQNNVFMSESKCWVENDINNGPHEFCSQHTMLVKM NC_001846_MHV_MHV-A59_nsp12_1357 VVCYNSEFASKGYIANISAFQQVLYYQNNVFMSEAKCWVETDIEKGPHEFCSQHTMLVKM NC_007732_PHEV_VW572_nsp12_13318 VVCYNSDYASKGYIANISAFQQVLYYQNNVFMSESKCWVENDINKGPHEFCSQHTMLVKM EF424621_AntelopeCoV_US/OH1/2003 VVCYNSDYASKGYIANISAFQQVLYYQNNVFMSESKCWVENDINNGPHEFCSQHTMLVKM EF424622_GiCoV_US/OH3-TC/2006_ns VVCYNSDYASKGYIANISAFQQVLYYQNNVFMSESKCWVENDINNGPHEFCSQHTMLVKM NC_004718_SARS-human_Tor2_nsp12_ VVCYNSNYAAQGLVASIKNFKAVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQ AY304488_SARS-civet_SZ16_nsp12_1 VVCYNSNYAAQGLVASIKNFKAVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQ NC_009694_SARS-bat_HKU3-1_nsp12_ VVCYNSNYAAQGLVASIKNFKAVLYYQNNVFMSEAKCWTETDLTRGPHEFCSQHTMLVKQ AY545919_SARS-badger_CFB/SZ/94/0 VVCYNSNYAAQGLVASIKNFKAVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQ NC_009019_Bat-CoV-HKU4_B04f VVCYNSDYAAKGYVASIQNFKETLYYQNNVFMSEAKCWVETNLEKGPHEFCSQHTLYIKD NC_009020_Bat-CoV-HKU5_LMH3f VVCYNSDYATKGYIASIQNFKETLYYQNNVFMSEAKCWVETDLKKGPHEFCSQHTLFIKD NC_009021_Bat-CoV-HKU9_BF_005I VVCYNADYAQKGYVADIQGFKELLYFQNNVFMSESKCWVEPDITKGPHEFCSQHTMLVDM NC_001451_IBV_Beaudette_nsp12_12 VVCYNNTLAKQGLVADISGFREVLYYQNNVFMADSKCWVEPDLEKGPHEFCSQHTMLVEV AY646283_IBV-partridge_Partridge VVCYNNTLAKQGLVADISGFREILYYQNNVYMADSKCWVEPDVEKGPHEF--------RV AY641576_IBV-peafowl_Peafowl/GD/ VVCYNNTLAKQGLVADISGFREILYYQNNVYMADSKCWVEPDLEKGPHEFCSQHTMLVEV ***** * * :..:. *. **:**.*:*: :*** * :: ***** NC_002645_HCoV-229E_inf-1_nsp12_ ENGKYYLPYPDPSRIISAGVFVDDITKTDAVILLERYVSLAIDAYPLSKHPKPEYRKVFY NC_005831_HCoV-NL63_AmsterdamI_n KDGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLERYVSLAIDAYPLSKHPNSEYRKVFY NC_002306_TGEV_PUR46-MAD_nsp12_1 PDGDYYLPYPDPSRILSAGVFVDDIVKTDNVIMLERYVSLAIDAYPLTKHPKPAYQKVFY NC_003436_PEDV_CV777_nsp12_12597 KEGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLERYVSLAIDAYPLSKHENPEYKKVFY DQ811787_PRCV_ISU-1_nsp12_12289. PDGDYYLPYPDPSRILSAGVFVDDIVKTDNVIMLERYVSLAIDAYPLTKHPKPAYQKVFY AY994055_FIPV_79-1146_nsp12_1238 PDGDYYLPYPDPSRILSAGVFVDDIVKTDNVIMLERYVSLAIDAYPLTKHPKPAYQKVFY NC_009657_BtCoV-G1_BtCoV/512/200 KDGTYYLPYPDPSRILSAGVFVDDIVKTDPVILLERYVSLAIDAYPLSKHDNPEYRRVFT EF203064_Bat-CoV-HKU2_HKU2/GD/43 SDGDYYLPYPDPSRILSAGVFVDDIVKTDPVILLERYVSLAIDAYPLSKHPNREYRKVFY NC_005147_HCoV-OC43_OC43_nsp12_1 DGDDVYLPYPNPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVYHENEEYQKVFR NC_006577_CoV-HKU1A_N1_nsp12_135 DGDYVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVHHENEEYQKVFR AY884001_CoV-HKU1B_N2_nsp12_1348 DGDYVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVHHENEEYQKVFR DQ339101_CoV-HKU1C_N5_nsp12_1342 DGDYVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVYHENEEYQKVFR NC_003045_BCoV_BCoV-ENT_nsp12_13 DGDDVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVYHENEEYQKVFR NC_001846_MHV_MHV-A59_nsp12_1357 DGDEVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVYHENPEYQNVFR NC_007732_PHEV_VW572_nsp12_13318 DGDDVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVYHENEEYQKVFR EF424621_AntelopeCoV_US/OH1/2003 DGDDVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVYHENEEYQKVFR EF424622_GiCoV_US/OH3-TC/2006_ns DGDDVYLPYPDPSRILGAGCFVDDLLKTDSVLLIERFVSLAIDAYPLVYHENEEYQKVFR NC_004718_SARS-human_Tor2_nsp12_ GDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFH AY304488_SARS-civet_SZ16_nsp12_1 GDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFH NC_009694_SARS-bat_HKU3-1_nsp12_ GDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFH AY545919_SARS-badger_CFB/SZ/94/0 GDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFH NC_009019_Bat-CoV-HKU4_B04f GDDGYFLPYPDPSRILSAGCFVDDIVKTDGTVMMERYVSLAIDAYPLTKHDDTEYQNVFW NC_009020_Bat-CoV-HKU5_LMH3f GDDGYFLPYPDPSRILSAGCFVDDIVKTDGTLMVERFVSLAIDAYPLTKHDDPEYQNVFW NC_009021_Bat-CoV-HKU9_BF_005I KGEQVYLPYPDPSRILGAGCFVDDLLKTDGTLMMERYVSLAIDAYPLTKHPDPEYQNVFW NC_001451_IBV_Beaudette_nsp12_12 DGEPKYLPYPDPSRILGACVFVDDVDKTEPVAVMERYIALAIDAYPLVHHENEEYKKVFF AY646283_IBV-partridge_Partridge DGEPRYLPYPDPSRILGACVFVDEVDKTEPVAVMERYIALAIDAYPLVHHENEEYRKVFF AY641576_IBV-peafowl_Peafowl/GD/ DGEPKYLPYPDPSRILCACVFVDDLDKTESVAVMERYIALAIDAYPLVHHENEEYKKVFF :****:****: * ***:: **: . ::**:::******** * . * ** NC_002645_HCoV-229E_inf-1_nsp12_ ALLDWVKHLNKTLNEGVLESFSVTLLDEHESKFWDESFYASMYEKSTVLQ NC_005831_HCoV-NL63_AmsterdamI_n VLLDWVKHLNKNLNEGVLESFSVTLLDNQEDKFWCEDFYASMYENSTILQ NC_002306_TGEV_PUR46-MAD_nsp12_1 TLLDWVKHLQKNLNAGVLDSFSVTMLEEGQDKFWSEEFYASLYEKSTVLQ NC_003436_PEDV_CV777_nsp12_12597 VLLDWVKHLYKTLNAGVLESFSVTLLEDSTAKFWDESFYANMYEKSAVLQ DQ811787_PRCV_ISU-1_nsp12_12289. TLLDWVKHLQKNLNAGVLDSFSVTMLEEGQDKFWSEEFYASLYEKSTVLQ AY994055_FIPV_79-1146_nsp12_1238 TLLDWVKHLQKNLNAGVLDSFSVTMLEEGQDKFWSEEFYASLYEKSTVLQ NC_009657_BtCoV-G1_BtCoV/512/200 VMLDWVKHLYKTLNQGVLDSFSVTLLEDATAKFWDESFYASMYEQSSVLQ EF203064_Bat-CoV-HKU2_HKU2/GD/43 VLLDWVKHLHNTLNQGILETFSVTLLDDVQSKFWDEAFYAGMYEKSTVLQ NC_005147_HCoV-OC43_OC43_nsp12_1 VYLAYIKKLYNDLGNQILDSYSVILSTCDGQKFTDESFYKNMYLRSAVMQ NC_006577_CoV-HKU1A_N1_nsp12_135 VYLEYIKKLYNDLGTQILDSYSVILSTCDGLKFTEESFYKNMYLKSAVMQ AY884001_CoV-HKU1B_N2_nsp12_1348 VYLEYIKKLYNDLGNQILDSYSVILSTCDGLKFTDESFYKNMYLKSAVMQ DQ339101_CoV-HKU1C_N5_nsp12_1342 VYLEYIKKLYNDLGTQILDSYSVILSTCDGLKFTEESFYKNMYLKSAVMQ NC_003045_BCoV_BCoV-ENT_nsp12_13 VYLEYIKKLYNDLGNQILDSYSVILSTCDGQKFTDESFYKNMYLRSAVMQ NC_001846_MHV_MHV-A59_nsp12_1357 VYLEYIKKLYNDLGNQILDSYSVILSTCDGQKFTDETFYKNMYLRSAVLQ NC_007732_PHEV_VW572_nsp12_13318 VYLEYIKKLYNDLGNQILDSYSVILSTCDGQKFTEESFYKNMYLRSAVMQ EF424621_AntelopeCoV_US/OH1/2003 VYLEYIKKLYNDLGNQILDSYSVILSTCDGQKFTDESFYKNMYLRSAVMQ EF424622_GiCoV_US/OH3-TC/2006_ns VYLEYIKKLYNDLGNQILDSYSVILSTCDGQKFTDESFYKNMYLRSAVMQ NC_004718_SARS-human_Tor2_nsp12_ LYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ AY304488_SARS-civet_SZ16_nsp12_1 LYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ NC_009694_SARS-bat_HKU3-1_nsp12_ LYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ AY545919_SARS-badger_CFB/SZ/94/0 LYLQYIKKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ NC_009019_Bat-CoV-HKU4_B04f VYLQYIEKLYKDLTGHMLDSYSVMLCGDDSAKFWEEGFYRDLYSSPTTLQ NC_009020_Bat-CoV-HKU5_LMH3f VYLQYIEKLYKDLTGHMLDSYSVMLCGDNSAKFWEESFYRDLYTAPTTLQ NC_009021_Bat-CoV-HKU9_BF_005I CYLQYIKKLHEELTGHLLDTYSVMLASDNASKYWEVEFYENMYMESATLQ NC_001451_IBV_Beaudette_nsp12_12 VLLAYIRKLYQELSQNMLMDYSFVMDIDKGSKFWEQEFYENMYRAPTTLQ AY646283_IBV-partridge_Partridge VLLSYIRKLYQELSQSMLIDYSFVMDIDKGSKFWEQEFYENMYRAPTTLQ AY641576_IBV-peafowl_Peafowl/GD/ VLLSYIRKLYQELSQNMLMDYSFVMDIDKGSKFWEQEFYENMYRAPTTLQ * :: :* . * :* :*. : .: ** :* : :*