NC_002645_HCoV-229E_inf-1_nsp14_ -SESSCGLFKDCARNPIDLPPSHATTYLSLSDRFKTSGDLAVQIGN--NNVCTYEHVISY NC_005831_HCoV-NL63_AmsterdamI_n -SSQVCGLFKNCTRTPLNLPPTHAHTFLSLSDQFKTTGDLAVQIGS--NNVCTYEHVISF NC_002306_TGEV_PUR46-MAD_nsp14_1 AKPETCGLFKDCSKSEQYIPPAYATTYMSLSDNFKTSDGLAVNIGT---KDVKYANVISY NC_003436_PEDV_CV777_nsp14_17168 -ANEGCGLFKDCSRGDDLLPPSHANTFMSLADNFKTDQYLAVQIGV--NGPIKYEHVISF DQ811787_PRCV_ISU-1_nsp14_16872. AKPETCGLFKDCSKSEQYIPPAYATTYMSLSDNFKTSDGLAVNIGT---KDVKYANVISY AY994055_FIPV_79-1146_nsp14_1696 AKPETCGLFKDCSKSEQYIPPAYATTYMSLSDNFKTSDGLAVNIGT---KDVKYANVISY NC_009657_BtCoV-G1_BtCoV/512/200 -VGDGCGLFKDCYKGEDNLPPSHAPTFMSLSDNFKTDKDLAVQIGV--NGPVKYEHVISF EF203064_Bat-CoV-HKU2_HKU2/GD/43 STIGGCGLFKDCYKFDQDLPPAHATTYMALSDKFKTDKELAVNIGH---SDVRYEHVVSY NC_005147_HCoV-OC43_OC43_nsp14_1 ---CSTNLFKDCSKSYSGYHPAHAPSFLAVDDKYKATGDLAVCLGI-GDSAVTYSRLISL NC_006577_CoV-HKU1A_N1_nsp14_181 ---CTTNLFKDCSKSCLGYHPAHAPSFLAVDDKYKVNENLAVNLNI-CEPVLTYSRLISL AY884001_CoV-HKU1B_N2_nsp14_1807 ---CTTNLFKDCSKNFLGYHPAHAPSFLSVDDKYKVNEDLAVCLNI-CEPVLTYSRLISL DQ339101_CoV-HKU1C_N5_nsp14_1801 ---CTTNLFKDCSKSCLGYHPAHAPSFLAVDDKYKVNENLAVNLNI-CEPVLTYSRLISL NC_003045_BCoV_BCoV-ENT_nsp14_17 ---CSTNLFKDCSKSYSGYHPAHAPSFLAVDDKYKATGDLAVCLGI-GDSAVTYSRLISL NC_001846_MHV_MHV-A59_nsp14_1816 ---CTTNLFKDCSRSYVGYHPAHAPSFLAVDDKYKVGGDLAVCLNV-ADSAVTYSRLISL NC_007732_PHEV_VW572_nsp14_17910 ---CSTNLFKDCSKNYSGYHPAYAPSFLAVDDKYKATGDLAVCLGI-SDSAVTYSRLISL EF424621_AntelopeCoV_US/OH1/2003 ---CSTNLFKDCSKSYSGYHPAHAPSFLAVDDKYKATGDLAVCLGI-GDSAVTYSRLISL EF424622_GiCoV_US/OH3-TC/2006_ns ---CSTNLFKDCSKSYSGYHPAHAPSFLAVDDKYKATGDLAVCLGI-GDSAVTYSRLISL NC_004718_SARS-human_Tor2_nsp14_ -AENVTGLFKDCSKIITGLHPTQAPTHLSVDIKFKTEG-LCVDIPG-IPKDMTYRRLISM AY304488_SARS-civet_SZ16_nsp14_1 -AENVTGLFKDCSKIITGLHPTQAPTHLSVDIKFKTEG-LCVDIPG-IPKDMTYRRLISM NC_009694_SARS-bat_HKU3-1_nsp14_ -AENVTGLFKDCSKIITGLHPTQAPTHLSVDTKFKTEG-LCVDIPG-IPKDMTYRRLISM AY545919_SARS-badger_CFB/SZ/94/0 -AENVTGLFKDCSKIITGLHPTQAPTHLSVDIKFKTEG-LCVDIPG-IPKDMTYRRLISM NC_009019_Bat-CoV-HKU4_B04f -SQIVTGLFKDCSREDTGLPPAYAPTYLSVDAKYKTTDELCVNLNI--TPNVTYSRVISR NC_009020_Bat-CoV-HKU5_LMH3f -SQIVTGLYKDCSRESSGLHPAYAPTYVSVDDKYKTSDELCVNLNV--PANVPYSRVISR NC_009021_Bat-CoV-HKU9_BF_005I -SEVTVGLFKDCAKAEP-LGPAYAPTFVSVNDKFKLNESLCVHFDT-TELQMPYNRLISK NC_001451_IBV_Beaudette_nsp14_16 ----GTGLFKICNKEFSGVHPAYAVTTKALAATYKVNDELAALVNVEAGSEITYKHLISL AY646283_IBV-partridge_Partridge ----GTGLFKICNKEFSGVHPAYAVTTKALAATYKVNDELAALVNIEAGSEITYKHLISL AY641576_IBV-peafowl_Peafowl/GD/ ----GTGLFKICNKEFSGVHPAYAVTTKALAATYKVNDELAALVNVEAGSEITYKHLISL .*:* * . *: * : :: :* *.. . * .::* NC_002645_HCoV-229E_inf-1_nsp14_ MGFRFDVSMPGSHSLFCTRDFAMRHVRGWLGMDVEGAHVTGDNVGTNVPLQVGFSNGVDF NC_005831_HCoV-NL63_AmsterdamI_n MGFRFDISIPGSHSLFCTRDFAIRNVRGWLGMDVESAHVCGDNIGTNVPLQVGFSNGVNF NC_002306_TGEV_PUR46-MAD_nsp14_1 MGFRFEANIPGYHTLFCTRDFAMRNVRAWLGFDVEGAHVCGDNVGTNVPLQLGFSNGVDF NC_003436_PEDV_CV777_nsp14_17168 MGFRFDINIPNHHTLFCTRDFAMRNVRGWLGFDVEGAHVVGSNVGTNVPLQLGFSNGVDF DQ811787_PRCV_ISU-1_nsp14_16872. MGFRFEANIPGYHTLFCTRDFAMRNVRAWLGFDVEGAHVCGDNVGTNVPLQLGFSNGVDF AY994055_FIPV_79-1146_nsp14_1696 MGFRFEANIPGYHTLFCTRDFAMRNVRAWLGFDVEGAHVCGDNVGTNVPLQLGFSNGVDF NC_009657_BtCoV-G1_BtCoV/512/200 MGFRFDINVPNQHTLFCTRDFAMRNARGWLGFDVEGAHVIGSNVGTNVPLQLGFSNGVDF EF203064_Bat-CoV-HKU2_HKU2/GD/43 MGFRFDMNIPNFHSLFCTRDFAMRNVRGWIGMDVEGAHVCGDNIGTNVPLQVGFSNGVDF NC_005147_HCoV-OC43_OC43_nsp14_1 MGFKLDVTLDGYCKLFITKEEAVKRVRAWVGFDAEGAHATRDSIGTNFPLQLGFSTGIDF NC_006577_CoV-HKU1A_N1_nsp14_181 MGFKLDLTLDGYSKLFITKDEAIKRVRGWVGFDVEGAHATRENIGTNFPLQIGFSTGVDF AY884001_CoV-HKU1B_N2_nsp14_1807 MGFKLDLTLDGYSKFFITKDEAIKRVRGWVGFDVEGAHATRDNIGTNFPLQIGFSTGVDF DQ339101_CoV-HKU1C_N5_nsp14_1801 MGFKLDLTLDGYSKLFITKDEAIKRVRGWVGFDVEGAHATRENIGTNFPLQIGFSTGVDF NC_003045_BCoV_BCoV-ENT_nsp14_17 MGFKLDVTLDGYCKLFITKEEAVKRVRAWVGFDAEGAHATRDSIGTNFPLQLGFSTGIDF NC_001846_MHV_MHV-A59_nsp14_1816 MGFKLDLTLDGYCKLFITRDEAIKRVRAWVGFDAEGAHAIRDSIGTNFPLQLGFSTGIDF NC_007732_PHEV_VW572_nsp14_17910 MGFKLDVTLDGYCKLFITKEEAVKRVRAWVGFDAEGAHATRDSIGTNFPLQLGFSTGIDF EF424621_AntelopeCoV_US/OH1/2003 MGFKLDVTLDGYCKLFITKEEAVKRVRAWVGFDAEGAHATRDNIGTNFPLQLGFSTGIDF EF424622_GiCoV_US/OH3-TC/2006_ns MGFKLDVTLDGYCKLFITKEEAVKRVRAWVGFDAEGAHATRDNIGTNFPLQLGFSTGIDF NC_004718_SARS-human_Tor2_nsp14_ MGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATRDAVGTNLPLQLGFSTGVNL AY304488_SARS-civet_SZ16_nsp14_1 MGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATRDAVGTNLPLQLGFSTGVNL NC_009694_SARS-bat_HKU3-1_nsp14_ MGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATRDAVGTNLPLQLGFSTGVNL AY545919_SARS-badger_CFB/SZ/94/0 MGFKMNYQVNGYPHMFITREEAIRHVRAWIGFDVEGCHATRDAVGTNLPLQLGFSTGVNL NC_009019_Bat-CoV-HKU4_B04f MGFKLDATIPGYPKLFITRDEAIRQVRSWVGFDVEGAHASRNACGTNVPLQLGFSTGVNF NC_009020_Bat-CoV-HKU5_LMH3f MGFKLDASIPNYPKLFITRDEAIRQVRSWIGFDVEGAHASRNACGTNVPLQLGFSTGVNF NC_009021_Bat-CoV-HKU9_BF_005I MGFKFDLNIPGYSKLFITREQAIREVRGWVGFDVEGAHACGPNIGTNLPLQIGFSTGVNF NC_001451_IBV_Beaudette_nsp14_16 LGFKMSVNVEGCHNMFITRDEAIRNVRGWVGFDVEATHACGTNIGTNLPFQVGFSTGADF AY646283_IBV-partridge_Partridge LGFKMSVNVEGCHNMFITRDEAIRNVRGWIGFDVEATHACGTNIGTNLPFQVGFSTGADF AY641576_IBV-peafowl_Peafowl/GD/ LGFKMSVNVEGCHNMFITRDEAIRNVRGWVGFDVEATHACGTNIGTNLPFQVGFSTGADF :**.:. : . :* *.: *:. .*.*:*:*.*. *. ***.*:*:***.* :: NC_002645_HCoV-229E_inf-1_nsp14_ VAQPEGCVLTNTGSVVKPVRARAPPGEQFTHIVPLLRKGQPWSVLRKRIVQMIADFLAGS NC_005831_HCoV-NL63_AmsterdamI_n VVQTEGCVSTNFGDVIKPVCAKSPPGEQFRHLIPLLRKGQPWLIVRRRIVQMISDYLSNL NC_002306_TGEV_PUR46-MAD_nsp14_1 VVQTEGCVITEKGNSIEVVKARAPPGEQFAHLIPLMRKGQPWHIVRRRIVQMVCDYFDGL NC_003436_PEDV_CV777_nsp14_17168 VVRPEGCVVTESGDYIKPVRARAPPGEQFAHLLPLLKRGQPWDVVRKRIVQMCSDYLANL DQ811787_PRCV_ISU-1_nsp14_16872. VVQTEGCVITEKGNSIEVVKARAPPGEQFSHLIPLMRKGQPWHIVRRRIVQMVCDYFDGL AY994055_FIPV_79-1146_nsp14_1696 VVQTEGCVVTEKGNSIEVVKARAPPGEQFAHLIPLMRKGQPWHIVRRRIVQMVCDYFDGL NC_009657_BtCoV-G1_BtCoV/512/200 VVRPEGCVSTEVGDVIQPVRARAPPGDQFTHLLPLLRKGQPWSVIRRRIVQMCSDYLANL EF203064_Bat-CoV-HKU2_HKU2/GD/43 VVQPEGCVVTNEGNIVKPVKARAPPGEQFTHLVPLMRKGQPWYVVRRRIVQMVCDCLNGL NC_005147_HCoV-OC43_OC43_nsp14_1 VVEATGLFADRDGYSFKKAVAKAPPGEQFKHLIPLMTRGHRWDVVRPRIVQMFADHLIDL NC_006577_CoV-HKU1A_N1_nsp14_181 VVEATGLFAERDCYTFKKTVAKAPPGEKFKHLIPLMSKGQKWDIVRIRIVQMLSDYLLDL AY884001_CoV-HKU1B_N2_nsp14_1807 VVEATGLFAERDCYIFKRTVAKAPPGDNFKHLIPLMSKGQKWDVVRIRIVQMLSDYLLDL DQ339101_CoV-HKU1C_N5_nsp14_1801 VVEATGLFAERDCYTFKKTVAKAPPGEKFKHLIPLMSKGQKWDIVRIRIVQMLSDYLLDL NC_003045_BCoV_BCoV-ENT_nsp14_17 VVEATGLFADRDGYSFKKAVAKAPPGEQFKHLIPLMTRGQRWDVVRPRIVQMFADHLIDL NC_001846_MHV_MHV-A59_nsp14_1816 VVEATGMFAERDGYVFKKAAARAPPGEQFKHLIPLMSRGQKWDVVRIRIVQMLSDHLADL NC_007732_PHEV_VW572_nsp14_17910 VVEATGLFADRDGYSFKKAVAKAPPGEQFKHLIPLMTRGQRWDVVRPRIVQMFADHLIDL EF424621_AntelopeCoV_US/OH1/2003 VVEATGLFADRDGYSFKKAVAKAPPGEQFKHLIPLMTRGQRWDVVRPRIVQMFADHLIDL EF424622_GiCoV_US/OH3-TC/2006_ns VVEATGLFADRDGYSFKKAVAKAPPGEQFKHLIPLMTRGQRWDVVRPRIVQMFADHLIDL NC_004718_SARS-human_Tor2_nsp14_ VAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGL AY304488_SARS-civet_SZ16_nsp14_1 VAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGL NC_009694_SARS-bat_HKU3-1_nsp14_ VAVPTGYVDTENSTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGL AY545919_SARS-badger_CFB/SZ/94/0 VAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGL NC_009019_Bat-CoV-HKU4_B04f VVQPVGVVDTEWGSMLTTISARPPPGEQFKHLVPLMNKGATWPIVRRRIVQMLSDTLDKL NC_009020_Bat-CoV-HKU5_LMH3f VVQPVGVVDTEWGSMLTSIAARPPPGEQFKHLVPLMNKGAAWPIVRRRIVQMLSDTLDKL NC_009021_Bat-CoV-HKU9_BF_005I VVTPSGYIDTESGSRLANVVSKAPPGDQFKHLIPLMRKGEPWSVVRKRIVEMLCDTLDGV NC_001451_IBV_Beaudette_nsp14_16 VVTPEGLVDTSIGNNFEPVNSKAPPGEQFNHLRVLFKSAKPWHVIRPRIVQMLADNLCNV AY646283_IBV-partridge_Partridge VVTPEGLVDTSIGNNFEPVNSKAPPGEQFNHLRALFKSAKPWHVIRPRIVQMLADNLCNV AY641576_IBV-peafowl_Peafowl/GD/ VVTPEGLVDTSIGNNFEPVNSKAPPGEQVNHLRALFKSAKPWHVVRPRIVQMLADNLCNV *. . * . . :..***::. *: *: . * ::* .**:* .* : NC_002645_HCoV-229E_inf-1_nsp14_ SDVLVFVLWAGGLELTTMRYFVKIGAVKHCQ-CGTVATCYNSVSNDYCCF---KHALGCD NC_005831_HCoV-NL63_AmsterdamI_n SDILVFVLWAGSLELTTMRYFVKIGPIKYCY-CGNSATCYNSVSNEYCCF---KHALGCD NC_002306_TGEV_PUR46-MAD_nsp14_1 SDILIFVLWAGGLELTTMRYFVKIGRPQKCE-CGKSATCYSSSQSVYACF---KHALGCD NC_003436_PEDV_CV777_nsp14_17168 SDILIFVLWAGGLELTTMRYFVKIGPSKSCD-CGKVATCYNSALHTYCCF---KHALGCD DQ811787_PRCV_ISU-1_nsp14_16872. SDILIFVLWAGGLELTTMRYFVKIGRPQKCE-CGKSATCYSSSQSVYACF---KHALGCD AY994055_FIPV_79-1146_nsp14_1696 SDILIFVLWAGGLELTTMRYFVKIGRPQKCE-CGKSATCYSSSQCVYACF---KHALGCD NC_009657_BtCoV-G1_BtCoV/512/200 SDTLIFVLWSGGLELTTMRYFVKLGPVQTCD-CGKRATCYNSTNHTFSCF---RHALGSD EF203064_Bat-CoV-HKU2_HKU2/GD/43 SDVVIFVLWAGGLELTTMKYFVKIGPSQHCD-CGKEARCYNSATHAYYCL---AHALGCD NC_005147_HCoV-OC43_OC43_nsp14_1 SDCVVLVTWAANFELTCLRYFAKVGREISCNVCTKRATVYNSRTGYYGCW---RHSVTCD NC_006577_CoV-HKU1A_N1_nsp14_181 SDSVVFITWSASFELTCLRYFAKLGRELNCNVCSNRATCYNSRTGYYGCW---RHSYTCD AY884001_CoV-HKU1B_N2_nsp14_1807 SDSVVFITWSASFELTCLRYFAKLGRELNCDVCPNRATCYNSRTGYYGCW---RHSYTCD DQ339101_CoV-HKU1C_N5_nsp14_1801 SDSVVFITWSASFELTCLRYFAKLGRELNCNVCSNRATCYNSRTGYYGCW---RHSYTCD NC_003045_BCoV_BCoV-ENT_nsp14_17 SDCVVLVTWAANFELTCLRYFAKVGREISCNVCTKRATAYNSRTGYYGCW---RHSVTCD NC_001846_MHV_MHV-A59_nsp14_1816 ADSVVLVTWAASFELTCLRYFAKVGREVVCSVCTKRATCFNSRTGYYGCW---RHSYSCD NC_007732_PHEV_VW572_nsp14_17910 SDCVVLVTWAANFELTCLRYFVKVGREICCNVCTKRATVYNSRTGYYGCW---RHSVTCD EF424621_AntelopeCoV_US/OH1/2003 SDCVVLVTWAANFELTCLRYFAKVGREISCNVCTKRATAYNSRTGYYGCW---RHSVTCD EF424622_GiCoV_US/OH3-TC/2006_ns SDCVVLVTWAANFELTCLRYFAKVGREISCNVCTKRATAYNSRTGYYGCW---RHSVTCD NC_004718_SARS-human_Tor2_nsp14_ SDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACW---NHSVGFD AY304488_SARS-civet_SZ16_nsp14_1 SDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACW---NHSVGFD NC_009694_SARS-bat_HKU3-1_nsp14_ SDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACW---NHSVGFD AY545919_SARS-badger_CFB/SZ/94/0 SDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACW---NHSVGFD NC_009019_Bat-CoV-HKU4_B04f SDYCTFVCWAHGFELTSASYFCKIGKEQRCSMCSRRASTFSSPLQSYACW---SHSSGYD NC_009020_Bat-CoV-HKU5_LMH3f SDYCTFVCWAHGFELTSASYFCKIGKEQRCCMCNRRASTYSSPLHSYACW---SHSSGYD NC_009021_Bat-CoV-HKU9_BF_005I SDTVTFVTWAHGFELTTLHYFAKVGPERKCFMCPRRATLFSSVYGAYSCWSHHRHIGGAD NC_001451_IBV_Beaudette_nsp14_16 SDCVVFVTWCHGLELTTLRYFVKIGKEQVCS-CGSRATTFNSHTQAYACW---KHCLGFD AY646283_IBV-partridge_Partridge SDCVVFVTWCHGLELTTLRYFVKIGKEQVCS-CGSRATTFNSHTQAYACW---KHCLGFD AY641576_IBV-peafowl_Peafowl/GD/ SDCVVFVTWCHGLELTTLRYFVKIGKDQVCS-CGSRATTFNSYTQAYACW---KHCLGFD :* :: *. .:*** ** *:* * * * :.: : * * * NC_002645_HCoV-229E_inf-1_nsp14_ YVYNPYVIDIQQWGYVGSLSTNHHAICNVHRNEHVASGDAIMTRCLAVYDCFVKNVDWSI NC_005831_HCoV-NL63_AmsterdamI_n YVYNPYAFDIQQWGYVGSLSQNHHTFCNIHRNEHDASGDAVMTRCLAVHDCFVKNVDWTV NC_002306_TGEV_PUR46-MAD_nsp14_1 YLYNPYCIDIQQWGYTGSLSMNHHEVCNIHRNEHVASGDAIMTRCLAIHDCFVKRVDWSI NC_003436_PEDV_CV777_nsp14_17168 YLYNPYCIDIQQWGYKGSLSLNHHEHCNVHRNEHVASGDAIMTRCLAIHDCFVKNVDWSI DQ811787_PRCV_ISU-1_nsp14_16872. YLYNPYCIDIQQWGYTGSLSMNHHEVCNIHRNEHVASGDAIMTRCLAIHDCFVKRIDWSI AY994055_FIPV_79-1146_nsp14_1696 YLYNPYCIDIQQWGYTGSLSMNHHEVCNIHRNEHVASGDAIMTRCLAIHDCFVKRVDWSI NC_009657_BtCoV-G1_BtCoV/512/200 YIYNCYCIDIQQWGYTGSLSMNHHEVCNIHRNEHVASGDAAMTRCLAIHDCFVKNVDWSI EF203064_Bat-CoV-HKU2_HKU2/GD/43 YLYNPFVIDIQQWGYTGSLSSNHHEVCNVHRNEHVASGDAIMTRCLAIHDCFVKNVDWSI NC_005147_HCoV-OC43_OC43_nsp14_1 YLYNPLIVDIQQWGYIGSLSSNHDLYCSVHKGAHVASSDAIMTRCLAVYDCFCNNINWNV NC_006577_CoV-HKU1A_N1_nsp14_181 YVYNPLIVDIQQWGYTGSLTSNHDIICNVHKGAHVASADAIMTRCLAIYDCFCKSVNWNL AY884001_CoV-HKU1B_N2_nsp14_1807 YVYNPLIVDIQQWGYTGSLTSNHDIICNVHKGAHVASSDAIMTRCLAIYDCFCKSVNWNL DQ339101_CoV-HKU1C_N5_nsp14_1801 YVYNPLIVDIQQWGYTGSLTSNHDIICNVHKGAHVASADAIMTRCLAIYDCFCKSVNWNL NC_003045_BCoV_BCoV-ENT_nsp14_17 YLYNPLIVDIQQWGYIGSLSSNHDLYCSVHKGAHVASSDAIMTRCLAVYDCFCNNINWNV NC_001846_MHV_MHV-A59_nsp14_1816 YLYNPLIVDIQQWGYTGSLTSNHDPICSVHKGAHVASSDAIMTRCLAVHDCFCKSVNWNL NC_007732_PHEV_VW572_nsp14_17910 YLYNPLIVDIQQWGYTGSLSSNHDLYCSIHKGAHVASSDAIMTRCLAVYDCFCNNINWNV EF424621_AntelopeCoV_US/OH1/2003 YLYNPLIVDIQQWGYIGSLSSNHDLYCSVHKGAHVASSDAIMTRCLAVYDCFCNNINWNV EF424622_GiCoV_US/OH3-TC/2006_ns YLYNPLIVDIQQWGYIGSLSSNHDLYCSVHKGAHVASSDAIMTRCLAVYDCFCNNINWNV NC_004718_SARS-human_Tor2_nsp14_ YVYNPFMIDVQQWGFTGNLQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSV AY304488_SARS-civet_SZ16_nsp14_1 YVYNPFMIDVQQWGFTGNLQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSV NC_009694_SARS-bat_HKU3-1_nsp14_ YVYNPFMIDVQQWGFTGNLQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSV AY545919_SARS-badger_CFB/SZ/94/0 YVYNPFMIDVQQWGFTGNLQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSV NC_009019_Bat-CoV-HKU4_B04f YVYNPFFVDVQQWGYVGNLATNHDRYCGIHAGAHVASSDAIMTRCLAIYDCFIERVDWDV NC_009020_Bat-CoV-HKU5_LMH3f YVYNPFFVDVQQWGYIGNLATNHDRYCSVHQGAHVASNDAVMTRCLAIHDCFIERVEWDI NC_009021_Bat-CoV-HKU9_BF_005I FVYNPFLVDVQQWGYVGNLQVNHDNVCDVHKGAHVASCDAIMTRCLAIHDCFCGEVNWDV NC_001451_IBV_Beaudette_nsp14_16 FVYNPLLVDIQQWGYSGNLQFNHDLHCNVHGHAHVASVDAIMTRCLAINNAFCQDVNWDL AY646283_IBV-partridge_Partridge FVYNPLLVDVQQWGYTGNLQFNHDLHCNVHGHAHVASADAVMTRCLAINNAFCKDVNWEL AY641576_IBV-peafowl_Peafowl/GD/ FVYNPLLVDIQQWGYSGNLQFNHDLHCNVHGHAHVASADAIMTRCLAINNAFCQDVNWDL ::** .*:****: *.* ** * :* * ** ** ******: :.* ::* : NC_002645_HCoV-229E_inf-1_nsp14_ TYPMIANENAINKGGRTVQSHIMRAAIKLYNPKAIHDIGNPKGIRCAVTD-AKWYCYDKN NC_005831_HCoV-NL63_AmsterdamI_n TYPFIANEKFINGCGRNVQGHVVRAALKLYKPSVIHDIGNPKGVRCAVTD-AKWYCYDKQ NC_002306_TGEV_PUR46-MAD_nsp14_1 VYPFIDNEEKINKAGRIVQSHVMKAALKIFNPAAIHDVGNPKGIRCATTP-IPWFCYDRD NC_003436_PEDV_CV777_nsp14_17168 TYPFIGNEAVINKSGRIVQSHTMRSVLKLYNPKAIYDIGNPKGIRCAVTD-AKWFCFDKN DQ811787_PRCV_ISU-1_nsp14_16872. VYPFIDNEDKINKAGRIVQSHVMKAALKIFNPAAIHDVGNPKGIRCATTP-IPWFCYDRD AY994055_FIPV_79-1146_nsp14_1696 VYPFIDNEEKINKAGRIVQSHVMKAALKIFNPAAIHDVGNPKGIRCATTP-IPWFCYDRD NC_009657_BtCoV-G1_BtCoV/512/200 TYPFIANEQAINKSGRLVQSHVMRAVLKLYNPKAIHDVGNPKGIRCVVTD-ASWYCYDKN EF203064_Bat-CoV-HKU2_HKU2/GD/43 TYPFIANENAINKSGRIVQSHIMKAALKVYNPKAVHDIGNPKGIRCAATN-VPWYCYDKQ NC_005147_HCoV-OC43_OC43_nsp14_1 EYPIISNELSINTSCRVLQRVILKAAMLCNRYTLCYDIGNPKAIACVKD--FDFKFYDAQ NC_006577_CoV-HKU1A_N1_nsp14_181 EYPIISNEVSINTSCRLLQRVMLKAAMLCNRYNLCYDIGNPKGLACVKD--YEFKFYDAF AY884001_CoV-HKU1B_N2_nsp14_1807 EYPIISNEVSINTSCRLLQRVMLKAAMLCNRYNLCYDIGNPKGIACVKD--YEFKFYDAS DQ339101_CoV-HKU1C_N5_nsp14_1801 EYPIISNEVSINTSCRLLQRVMLKAAMLCNRYNLCYDIGNPKGLACVKD--YEFKFYDAF NC_003045_BCoV_BCoV-ENT_nsp14_17 EYPIISNELSINTSCRVLQRVMLKAAMLCNRYTLCYDIGNPKAIACVKD--FDFKFYDAQ NC_001846_MHV_MHV-A59_nsp14_1816 EYPIISNEVSVNTSCRLLQRVMFRAAMLCNRYDVCYDIGNPKGLACVKG--YDFKFYDAS NC_007732_PHEV_VW572_nsp14_17910 EYPIISNELSINTSCRVLQRVMLKAAMLCNRYSLCYDIGNPKAIACVKD--FDFKFYDAQ EF424621_AntelopeCoV_US/OH1/2003 EYPIISNELSINTSCRVLQRVMLKAAMLCNRYTLCYDIGNPKAIACVKD--FDFKFYDAQ EF424622_GiCoV_US/OH3-TC/2006_ns EYPIISNELSINTSCRVLQRVMLKAAMLCNRYTLCYDIGNPKAIACVKD--FDFKFYDAQ NC_004718_SARS-human_Tor2_nsp14_ EYPIIGDELRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAIKCVPQAEVEWKFYDAQ AY304488_SARS-civet_SZ16_nsp14_1 EYPIIGDELRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAIKCVPQAEVEWKFYDAQ NC_009694_SARS-bat_HKU3-1_nsp14_ EYPIIGDELKINAACRKVQHMVVKSALLADKFTVLHDIGNPKAIRCVPQAEVDWKFYDAQ AY545919_SARS-badger_CFB/SZ/94/0 EYPIIGDELRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAIKCVPQAEVEWKFYDAQ NC_009019_Bat-CoV-HKU4_B04f TYPYISHEQKLNSCCRTVERNVVRSAVLSGKFEKIYDIGNPKGIAIISEP-VEWHFYDAQ NC_009020_Bat-CoV-HKU5_LMH3f TYPYISHEKRLNSCCRAVERNVVRAALLAGRFERVYDIGNPKGIPIVDDPVVDWHYYDAQ NC_009021_Bat-CoV-HKU9_BF_005I EYPIIANELAINRACRSVQRVVLKAAVKALHIETIYDIGNPKAIKVYGVNVNNWNFYDTN NC_001451_IBV_Beaudette_nsp14_16 TYPHIANEDEVNSSCRYLQRMYLNACVDALKVNVVYDIGNPKGIKCVRRGDVNFRFYDKN AY646283_IBV-partridge_Partridge TYPHIANEDEVNSSCRYLQRMYLNACVDALKVNVVYDIGNPKGIKCVRRGDLTFRFYDKN AY641576_IBV-peafowl_Peafowl/GD/ TYPHIANEDEVNSSCRYLQRMYLNACVDALKVNVVYDIGNPKGIKCVRRGDLNFRFYDKN ** * * :* * :: ..: : . :*:****.: : :* NC_002645_HCoV-229E_inf-1_nsp14_ PINS---NVKTLEYDYMTHGQ--MDGLCLFWNCNVDMYPEFSIVCRFDTRTRSTLNLEGV NC_005831_HCoV-NL63_AmsterdamI_n PVNS---NVKLLDYDYATHGQ--LDGLCLFWNCNVDMYPEFSIVCRFDTRTRSVFNLEGV NC_002306_TGEV_PUR46-MAD_nsp14_1 PINN---NVRCLDYDYMVHGQ--MNGLMLFWNCNVDMYPEFSIVCRFDTRTRSKLSLEGC NC_003436_PEDV_CV777_nsp14_17168 PTNS---NVKTLEYDYITHGQ--FDGLCLFWNCNVDMYPEFSVVCRFDTRCRSPLNLEGC DQ811787_PRCV_ISU-1_nsp14_16872. PINN---NVRCLDYDYMVHGQ--MNGLMLFWNCNVDMYPEFSIVCRFDTRTRSKLSLEGC AY994055_FIPV_79-1146_nsp14_1696 PINN---NVRCLEYDYMVHGQ--MNGLMLFWNCNVDMYPEFSIVCRFDTRTRSKLSLEGC NC_009657_BtCoV-G1_BtCoV/512/200 PTNT---NVKMLEYDYITHGQ--LDGLCLFWNCNVDMYPEFSVVCRFDTRMRSTLNLEGC EF203064_Bat-CoV-HKU2_HKU2/GD/43 PINS---NVKMLEYDYMTHGQ--LDGMCLFWNCNVDMYPEFSIVCRFDTRCRSHLSLEGV NC_005147_HCoV-OC43_OC43_nsp14_1 PIVK---SVKTLLYSFEAHKDSFKDGLCMFWNCNVDKYPPNAVVCRFDTRVLNNLNLPGC NC_006577_CoV-HKU1A_N1_nsp14_181 PVAK---SVKQLFYVYDVHKDNFKDGLCMFWNCNVDKYPSNSIVCRFDTRVLNKLNLPGC AY884001_CoV-HKU1B_N2_nsp14_1807 PVVK---SVKQLFYVYDVHKDNFKDGLCMFWNCNVDKYPSNSIVCRFDTRVLNKLNLPGC DQ339101_CoV-HKU1C_N5_nsp14_1801 PVAK---SVKQLFYVYDVHKDNFKDGLCMFWNCNVDKYPSNSIVCRFDTRVLNKLNLPGC NC_003045_BCoV_BCoV-ENT_nsp14_17 PIVK---SVKTLLYSFEAHKDSFKDGLCMFWNCNVDKYPPNAVVCRFDTRVLNNLNLPGC NC_001846_MHV_MHV-A59_nsp14_1816 PVVK---SVKQFVYKYEAHKDQFLDGLCMFWNCNVDKYPANAVVCRFDTRVLNKLNLPGC NC_007732_PHEV_VW572_nsp14_17910 PIVK---SVKTLLYSFEAHKDSFKDGLCMFWNCNVDKYPPNAVVCRFDTRVLNNLNLPGC EF424621_AntelopeCoV_US/OH1/2003 PIVK---SVKTLLYSFEAHKDSFKDGLCMFWNCNVDKYPPNAVVCRFDTRVLNNLNLPGC EF424622_GiCoV_US/OH3-TC/2006_ns PIVK---SVKTLLYSFEAHKDSFKDGLCMFWNCNVDKYPPNAVVCRFDTRVLNNLNLPGC NC_004718_SARS-human_Tor2_nsp14_ PCSDKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGC AY304488_SARS-civet_SZ16_nsp14_1 PCSDKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGC NC_009694_SARS-bat_HKU3-1_nsp14_ PCSDKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGC AY545919_SARS-badger_CFB/SZ/94/0 PCSDKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGC NC_009019_Bat-CoV-HKU4_B04f PLSN---KVKKLFYTDD-VSKQFEDGLCLFWNCNVSKYPSNAVVCRFDTRVHSEFNLPGC NC_009020_Bat-CoV-HKU5_LMH3f PLSK---KVQQLFYTED-CAKNFSDGLCLFWNCNVPRYPNNAIVCRFDTRVHSEFNLPGC NC_009021_Bat-CoV-HKU9_BF_005I PVVE---GVKQLHYVYDVHRDQFKDGLAMFWNCNVDCYPHNALVCRFDTRVLSKLNLAGC NC_001451_IBV_Beaudette_nsp14_16 PIVR---NVKQFEYDYNQHKDKFADGLCMFWNCNVDCYPDNSLVCRYDTRNLSVFNLPGC AY646283_IBV-partridge_Partridge PIVP---NVKQFEYDYSQHKDKFADGLCMFWNCNVDCYPDNSLVCRYDTRNLSVFNLPGC AY641576_IBV-peafowl_Peafowl/GD/ PIVP---NVKQFEYDYNQHKDKFADGLCMFWNCNVDCYPDNSLVCRYDTRNLSVFNLPGC * : : * . :*: :****** ** ::***:*** . :.* * NC_002645_HCoV-229E_inf-1_nsp14_ NGGSLYVNNHAFHTPAYDKRAMAKLKPAPFFYYDDGSCEVV-------HDQVNYVPLRAT NC_005831_HCoV-NL63_AmsterdamI_n NGGSLYVNKHAFHTPAYDKRAFVKLKPMPFFYFDDSDCDVV-------QEQVNYVPLRAS NC_002306_TGEV_PUR46-MAD_nsp14_1 NGGALYVNNHAFHTPAYDRRAFAKLKPMPFFYYDDSNCELV-------DGQPNYVPLKSN NC_003436_PEDV_CV777_nsp14_17168 NGGSLYVNNHAFHTPAFDKRAFAKLKPMPFFFYDDTECDKL-------QDSINYVPLRAS DQ811787_PRCV_ISU-1_nsp14_16872. NGGALYVNNHAFHTPAYDRRAFAKLKPMPFFYYDDSNCELV-------DGQPNYVPLKSN AY994055_FIPV_79-1146_nsp14_1696 NGGALYVNNHAFHTPAYDRRAFAKLKPMPFFYYDDSNCELV-------DGQPNYVPLKSN NC_009657_BtCoV-G1_BtCoV/512/200 NGGSLYVNNHAFHTPAYDKRAFAKLKAMPFFFYDDSECEKL-------QDAVNYVPLRAS EF203064_Bat-CoV-HKU2_HKU2/GD/43 NGGALYVNNHAFHTPAYDKRAFAKLKPMPFFFYDDGECDVS-------QGQINYVPLRAT NC_005147_HCoV-OC43_OC43_nsp14_1 NGGSLYVNKHAFHTKPFARAAFEHLKPMPFFYYSDTPCVYM---DGMDAKQVDYVPLKSA NC_006577_CoV-HKU1A_N1_nsp14_181 NGGSLYVNKHAFHTNPFTRTVFENLKPMPFFYYSDTPCVYV---DGLESKQVDYVPLRSA AY884001_CoV-HKU1B_N2_nsp14_1807 NGGSLYVNKHAFHTNPFTRTVFENLKPMPFFYYSDTPCVYV---DGLESKQVDYVPLRSA DQ339101_CoV-HKU1C_N5_nsp14_1801 NGGSLYVNKHAFHTNPFTRTVFENLKPMPFFYYSDTPCVYV---DGLESKQVDYVPLRSA NC_003045_BCoV_BCoV-ENT_nsp14_17 NGGSLYVNKHAFHTKPFSRAAFEHLKPMPFFYYSDTPCVYM---DGMDAKQVDYVPLKSA NC_001846_MHV_MHV-A59_nsp14_1816 NGGSLYVNKHAFHTSPFTRAAFENLKPMPFFYYSDTPCVYM---EGMESKQVDYVPLRSA NC_007732_PHEV_VW572_nsp14_17910 NGGSLYVNKHAFHTKPFSRAAFEYLKPMPFFYYSDTPCVYM---DGMDAKQVDYVPLKSA EF424621_AntelopeCoV_US/OH1/2003 NGGSLYVNKHAFHTKPFSRAAFEHLKPMPFFYYSDTPCVYM---DGMDAKQVDYVPLKSA EF424622_GiCoV_US/OH3-TC/2006_ns NGGSLYVNKHAFHTKPFSRAAFEHLKPMPFFYYSDTPCVYM---DGMDAKQVDYVPLKSA NC_004718_SARS-human_Tor2_nsp14_ DGGSLYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPCESH---GKQVVSDIDYVPLKSA AY304488_SARS-civet_SZ16_nsp14_1 DGGSLYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPCESH---GKQVVSDIDYVPLKSA NC_009694_SARS-bat_HKU3-1_nsp14_ DGGSLYVNKHAFHTPAFDKSAFTHLKQLPFFYYSDSPCESH---GKQVVSDIDYVPLKSA AY545919_SARS-badger_CFB/SZ/94/0 DGGSLYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPCESH---GKQVVSDIDYVPLKSA NC_009019_Bat-CoV-HKU4_B04f NGGSLYVNKHAFHTPAYDINAFRDLKPLPFFYYSTTPCEVHG--SGNMLEDIDYVPLKSA NC_009020_Bat-CoV-HKU5_LMH3f DGGSLYVNKHAFHTPAYDASAFRDLKPLPFFYYSTTPCEVHG--NGNMLEDIDYVPLKSA NC_009021_Bat-CoV-HKU9_BF_005I NGGSLYVNQHAFHTDAFNKNAFVNLKPLPFFYYSDTACENATGVSTNYVSEVDYVPLKSN NC_001451_IBV_Beaudette_nsp14_16 NGGSLYVNKHAFYTPKFDRISFRNLKAMPFFFYDSSPCETI----QVDGVAQDLVSLATK AY646283_IBV-partridge_Partridge NGGSLYVNKHAFHTPKFERVSFRNLKAMPFFFYDSSPCETI----QVDGVAQDLVSLATK AY641576_IBV-peafowl_Peafowl/GD/ NGGSLYVNKHAFHTPKFDRTSFRNLKAMPFFFYDSSPCETI----QVDGVAQDLVSLATK :**:****:***:* : : ** ***::. * : *.* : NC_002645_HCoV-229E_inf-1_nsp14_ NCITKCNIGGAVCSKHANLYRAYVESYNIFTQAGFNIWVPTTFDCYNLWQTFTEVN-LQ NC_005831_HCoV-NL63_AmsterdamI_n SCVTRCNIGGAVCSKHANLYQKYVEAYNTFTQAGFNIWVPHSFDVYNLWQIFIETN-LQ NC_002306_TGEV_PUR46-MAD_nsp14_1 VCITKCNIGGAVCKKHAALYRAYVEDYNIFMQAGFTIWCPQNFDTYMLWHGFVNSKALQ NC_003436_PEDV_CV777_nsp14_17168 NCITKCNVGGAVCSKHCAMYHSYVNAYNTFTSAGFTIWVPTSFDTYNLWQTFSN-N-LQ DQ811787_PRCV_ISU-1_nsp14_16872. VCITKCNIGGAVCKKHAALYRAYVEDYNIFMQAGFTIWCPQNFDTYMLWHGFVNSKALQ AY994055_FIPV_79-1146_nsp14_1696 VCITKCNIGGAVCKKHAALYRAYVEDYNMFMQAGFTIWCPQNFDTYMLWHGFVNSKALQ NC_009657_BtCoV-G1_BtCoV/512/200 NCITRCNVGGAVCSKHCALYHNYVMAYNTFTTAGFTIWVPNSFDMFNLWQTFKNSN-VQ EF203064_Bat-CoV-HKU2_HKU2/GD/43 VCITKCNIGGAVCKRHASLYRAYVEAYNTFTQNGFNIWCPNSFDVYNLWQTLVDTN-LQ NC_005147_HCoV-OC43_OC43_nsp14_1 TCITRCNLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTK---LQ NC_006577_CoV-HKU1A_N1_nsp14_181 TCITRCNLGGAVCSKHAEEYCNYLESYNIVTTAGFTFWVYKNFDFYNLWNTFTT---LQ AY884001_CoV-HKU1B_N2_nsp14_1807 TCITRCNLGGAVCSKHAEDYCKYLESYNVATTAGFTFWVYKTFDFYNLWNTFTM---LQ DQ339101_CoV-HKU1C_N5_nsp14_1801 TCITRCNLGGAVCSKHAEEYCNYLESYNIVTTAGFTFWVYKTFDFYNLWNTFTT---LQ NC_003045_BCoV_BCoV-ENT_nsp14_17 TCITRCNLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTK---LQ NC_001846_MHV_MHV-A59_nsp14_1816 TCITRCNLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTR---LQ NC_007732_PHEV_VW572_nsp14_17910 TCITRCNLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTK---LQ EF424621_AntelopeCoV_US/OH1/2003 TCITRCNLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTK---LQ EF424622_GiCoV_US/OH3-TC/2006_ns TCITRCNLGGAVCLKHAEEYREYLESYNTATTAGFTFWVYKTFDFYNLWNTFTK---LQ NC_004718_SARS-human_Tor2_nsp14_ TCITRCNLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQFDTYNLWNTFTR---LQ AY304488_SARS-civet_SZ16_nsp14_1 TCITRCNLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQFDTYNLWNTFTR---LQ NC_009694_SARS-bat_HKU3-1_nsp14_ TCITRCNLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQFDTYNLWNTFTK---LQ AY545919_SARS-badger_CFB/SZ/94/0 TCITRCNLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQFDTYNLWNTFTR---LQ NC_009019_Bat-CoV-HKU4_B04f VCITACNLGGAVCRKHAAEYRDYMEAYNIVSAAGFRLWVYKTFDIYNLWSTFVK---VQ NC_009020_Bat-CoV-HKU5_LMH3f VCITACNLGGAVCRKHAAEYRDYMEAYNLVSASGFRLWCYKTFDVYNLWSTFTK---IQ NC_009021_Bat-CoV-HKU9_BF_005I VCITRCNLGGAVCKKHADEYRNFLESYNTMVSAGFTLWVDKTFDVFNLWSTFVK---LQ NC_001451_IBV_Beaudette_nsp14_16 DCITKCNIGGAVCKKHAQMYAEFVTSYNAAVTAGFTFWVTNKLNPYNLWKSFSA---LQ AY646283_IBV-partridge_Partridge DCITKCNIGGAVCKKHAQMYAEFVASYNAAVTAGFTFWVSNQFNPYNLWKNFSA---LQ AY641576_IBV-peafowl_Peafowl/GD/ DCITKCNIGGAVCKKHAQMYADFVTSYNAAVTAGFTFWVTNNFNPYNLWKSFSA---LQ *:* **:***** .*. * :: ** ** :* :: : ** : :*