NC_002645_HCoV-229E_inf-1_nsp4_7 -------GDAGHSLTWLW---LLCGLVCLIQFYLCFF-MPYFMYDIVSSFEG------YD NC_005831_HCoV-NL63_AmsterdamI_n --------GFKRTYNFLW---YVCLFVVALFIGVSFID---YTTTVTSFHG-------YD NC_002306_TGEV_PUR46-MAD_nsp4_74 ---SGFFDVITQLKQI-----VILVFVFIFICGLCSVYSVATQSYIESAEG-------YD NC_003436_PEDV_CV777_nsp4_7848.. -----GLPSFSKVKKFFW---FLCLFIVAAFFALSFLDFSTQVSSDSD----------YD DQ811787_PRCV_ISU-1_nsp4_7459..8 ---SGFFDVITQLKQI-----VILVFVFIFICGLCSVYSVATQSYIESAEG-------YD AY994055_FIPV_79-1146_nsp4_7550. ---SGFFDVLKQLKQLFW-----CLVLFITLYGLCSVYSVATQSYIDSAEG-------YD NC_009657_BtCoV-G1_BtCoV/512/200 ----GLPSLFTRLYSFFW---HLCVLIVVLFVATSLLDFSAQVTSDTQ----------YD EF203064_Bat-CoV-HKU2_HKU2/GD/43 -------GKLSSMWKNFW---YACGAILALFVLLNCVGFTEYASSLPG----------YD NC_005147_HCoV-OC43_OC43_nsp4_84 -----------AVFSYFV---YVCFVLSLVCFIGLWCLMPTYTVHKSDFQLP----VYAS NC_006577_CoV-HKU1A_N1_nsp4_8720 -------VVLSNLL-------YILFFVSLICFILLWALLPTYSVYKSDIHLP----AYAS AY884001_CoV-HKU1B_N2_nsp4_8624. -------VVLSNLL-------YILFFISLICFILLWALLPTYSVYKSDIHLP----AYAS DQ339101_CoV-HKU1C_N5_nsp4_8564. -------VVLSNLL-------YILFFISLICFILLWALLPTYSVYKSDIHLP----AYAS NC_003045_BCoV_BCoV-ENT_nsp4_846 -----------AVFSYFV---YVCFLLSLVCFIGLWCLMPTYTVHKSDFQLP----VYAS NC_001846_MHV_MHV-A59_nsp4_8721. -------AVFSRMLQW-------LFVANLICFIVLWALMPTYAVHKSDMQLP----LYAS NC_007732_PHEV_VW572_nsp4_8461.. -----------AVFSYFV---YVCFVLSLICFIGLWCLMPTYAVYKSDFQLP----VYAS EF424621_AntelopeCoV_US/OH1/2003 -----------AVFSYFV---YVCFLLSLVCFIGLWCLMPTYTVQKSDFQLP----VYAS EF424622_GiCoV_US/OH3-TC/2006_ns -----------AVFSYFV---YVCFLLSLVCFIGLWCLMPTYTVQKSDFQLP----VYAS NC_004718_SARS-human_Tor2_nsp4_8 -------KIVSTCFKLM----LKATLLCVLAALVCYIVMPVHTLSIHDGYTN----EIIG AY304488_SARS-civet_SZ16_nsp4_84 -------KIVSTWFKLM----LKATLLCVLAALVCYIVMPVHTLSIHDGYTN----EIIG NC_009694_SARS-bat_HKU3-1_nsp4_8 -------KVVSTWFKLL----LKVTLLCVLAALFCYVIMPVHSLSVHDGYTN----EIIG AY545919_SARS-badger_CFB/SZ/94/0 -------KIVSTWFKLM----LKATLLCVLAALVCYIVMPVHTLSIHDGYTN----EIIG NC_009019_Bat-CoV-HKU4_B04f ----GAPSWLLRVRDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDD----RILT NC_009020_Bat-CoV-HKU5_LMH3f ----GAPKWLLKLRDFTWKSYCVVTLVVFAMAVLSYLCLPAFNMSQVSFHED----RILT NC_009021_Bat-CoV-HKU9_BF_005I -----GHRRIVSWRRV-----LIHVFMLLVVLNPQWF-TPWYIMRPIEYNV-------VD NC_001451_IBV_Beaudette_nsp4_732 GIVSGTFKCFKSYFKW-----LLIFYILFTACCSGYYYMEVSKSFVHPMYDVNSTLHVEG AY646283_IBV-partridge_Partridge GVISSTVNRFKSCCKW-----LLVFYLLFTACCLCYYQWEMSKEFAHPMYDVNSTMHVEG AY641576_IBV-peafowl_Peafowl/GD/ GVINNTFKWFMSCFKW-----LFVFYILFTACCLGYYYMEMNKSFVHPMYDVNSTLHVEG NC_002645_HCoV-229E_inf-1_nsp4_7 FKYIENGQLKNFEAPLKCVRNVFENFEDWHYAKFGFT-PLNKQSCPIVVGVS---EIVNT NC_005831_HCoV-NL63_AmsterdamI_n FKYIENGQLKVFEAPLHCVRNVFDNFNQWHEAKFGVV-TTNSDKCPIVVGVS---ERINV NC_002306_TGEV_PUR46-MAD_nsp4_74 YMVIKNGIVQPFDDTISCVHNTYKGFGDWFKAKYGFI-PTFGKSCPIVVGTVFDLENMRP NC_003436_PEDV_CV777_nsp4_7848.. FKYIESGQLKTFDNPLSCVHNVFINFDQWHDAKFGFT-PVNNPSCPIVVGVS---DEART DQ811787_PRCV_ISU-1_nsp4_7459..8 YMVIKNGIVQPFDDTISCVHNTYKGFSDWFKAKYGFI-PTFGKSCPIVVGTVFDLENMRP AY994055_FIPV_79-1146_nsp4_7550. YMVIKNGVVQSFDDSINCVHNTYKGFAVWFKAKHGFV-PTFDKSCPIVLGTVFDLGNMRP NC_009657_BtCoV-G1_BtCoV/512/200 FKYIENGVLKVFEKPLDCVHNAFVNFNEWHNAKFGSI-PTNSRRCPIVVGTS---DEVRY EF203064_Bat-CoV-HKU2_HKU2/GD/43 FKYIEDGQLKPFVNGLYCVRNTFDTFMDWHAQKFGFK-PSNSDKCPIVVGAS---DSGRV NC_005147_HCoV-OC43_OC43_nsp4_84 YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVI-DQDFGST NC_006577_CoV-HKU1A_N1_nsp4_8720 FKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVVAVM-DEDIGST AY884001_CoV-HKU1B_N2_nsp4_8624. FKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSFYYHNSMDCPIVVAVM-DEDIGST DQ339101_CoV-HKU1C_N5_nsp4_8564. FKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVVAVM-DEDIGST NC_003045_BCoV_BCoV-ENT_nsp4_846 YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVV-DQDLGST NC_001846_MHV_MHV-A59_nsp4_8721. FKVIDNGVLRDVSVTDACFANKFNQFDQWYESTFGLAYYRNSKACPVVVAVI-DQDIGHT NC_007732_PHEV_VW572_nsp4_8461.. YKVLDNGVIRDISVEDVCFANKFEQFDQWYESTFGLNYYSNNMACPIVVAVI-DQDIGST EF424621_AntelopeCoV_US/OH1/2003 YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVV-DQDFGST EF424622_GiCoV_US/OH3-TC/2006_ns YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVV-DQDFGST NC_004718_SARS-human_Tor2_nsp4_8 YKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVAAII-TREIGFI AY304488_SARS-civet_SZ16_nsp4_84 YKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVAAII-TREIGFI NC_009694_SARS-bat_HKU3-1_nsp4_8 YKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRGGS--YRNDKNCPVVAAII-TREIGFI AY545919_SARS-badger_CFB/SZ/94/0 YKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVAAII-TREIGFI NC_009019_Bat-CoV-HKU4_B04f YKVIENGIVRDIAPNDVCFANKYGHFSKWFNENHGGV-YRNSMDCPITIAVI-AGVAGAR NC_009020_Bat-CoV-HKU5_LMH3f YKVVENGIIRDITPSDTCFANKYQSFSKWFNEHYGGL-FNNDISCPVTVAVI-AGVAGAR NC_009021_Bat-CoV-HKU9_BF_005I FKVIDNAVIRDITSADQCFANKFSAFENWYSNRYGS--YVNSRGCPMVVGVV-SDIVGSL NC_001451_IBV_Beaudette_nsp4_732 FKVIDKGVLREIVPEDTCFSNKFVNFDAFWGRP-----YDNSRNCPIVTAVI--DGDGTV AY646283_IBV-partridge_Partridge FKVIDKGVLRDIMLEDTCFSNKYVNFDSFWGKP-----YVNSRDCPIVIAII--DGAGTV AY641576_IBV-peafowl_Peafowl/GD/ FKVIDKGVIREIVSEDNCFSNKFVNFDAFWGKS-----YENNKNCPIVTVVI--DGDGTV : :... . . *. * . * : **:. NC_002645_HCoV-229E_inf-1_nsp4_7 VAGIPSNVYL-VGKTLI----------FTLQAAFGNAG-VCYDIFGVTTPEK-----CIF NC_005831_HCoV-NL63_AmsterdamI_n VPGVPTNVYL-VGKTLV----------FTLQAAFGNTG-VCYDFDGVTTSDK-----CIF NC_002306_TGEV_PUR46-MAD_nsp4_74 IPDVPAYVSI-VGRSLV----------FAINAAFGVTN-MCYDHTGNAVSKDSYFDTCVF NC_003436_PEDV_CV777_nsp4_7848.. VPGIPAGVYL-AGKTLV----------FAINTIFGTSG-LCFDASGVADKGA-----CIF DQ811787_PRCV_ISU-1_nsp4_7459..8 IPDVPAYVSI-VGRSLV----------FAINAAFGVTN-MCYDHTGNAVSKDSYFDTCVF AY994055_FIPV_79-1146_nsp4_7550. IPDVPAYVAL-VGRSLV----------FAINAAFGVTN-VCYDHTGAAVSKNSYFDTCVF NC_009657_BtCoV-G1_BtCoV/512/200 IPGVPAGVFL-YGKSLI----------FAMSTIFGTSG-LCFDDRGLTDPDS-----CIF EF203064_Bat-CoV-HKU2_HKU2/GD/43 VPGVASDVYL-LGKTLI----------FTLKTVFGSAG-HCYDVNGIADGDK-----CLF NC_005147_HCoV-OC43_OC43_nsp4_84 VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL NC_006577_CoV-HKU1A_N1_nsp4_8720 MFNVPTKVLR-HGFHVL----------HFLTYAFASDSVQCYTPHIQISYNDFYASGCVL AY884001_CoV-HKU1B_N2_nsp4_8624. MFNVPTKVLR-HGFHVL----------HFLTYAFASDSVQCYTPHIQISYNDFYASGCVL DQ339101_CoV-HKU1C_N5_nsp4_8564. MFNVPTKVLR-YGFHVL----------HFLTYAFASDSVQCYTPHIQISYNDFYASGCVL NC_003045_BCoV_BCoV-ENT_nsp4_846 VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL NC_001846_MHV_MHV-A59_nsp4_8721. LFNVPTTVLR-YGFHVL----------HFITHAFATDSVQCYTPHMQIPYDNFYASGCVL NC_007732_PHEV_VW572_nsp4_8461.. VFNVPTKVLR-YGYHVL----------HFITHAFSADGVQCYTPHSQISYSTFYASGCVL EF424621_AntelopeCoV_US/OH1/2003 VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL EF424622_GiCoV_US/OH3-TC/2006_ns VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL NC_004718_SARS-human_Tor2_nsp4_8 VPGLPGTVLRAINGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL AY304488_SARS-civet_SZ16_nsp4_84 VPGLPGTVLRAINGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL NC_009694_SARS-bat_HKU3-1_nsp4_8 VPGLPGTVLRALNGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL AY545919_SARS-badger_CFB/SZ/94/0 VPGLPGTVLRAINGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL NC_009019_Bat-CoV-HKU4_B04f VANVPANLAW-VGKQIV----------LFVSRVFANTN-VCFTPINEIPYDTFSDSGCVL NC_009020_Bat-CoV-HKU5_LMH3f VPNLPANVAW-VGRQIV----------LFVSRVFASSNNVCYTPTAEIPYERFSDSGCVL NC_009021_Bat-CoV-HKU9_BF_005I VPGLPARFLR-VGTTLL----------PLVNYGLGAVGSVCYTPHYAINYDVFDTSACVL NC_001451_IBV_Beaudette_nsp4_732 ATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFNREI-VGYTQDSIITEGSFYTSIALF AY646283_IBV-partridge_Partridge AAGVPGFVQWVMDGVMFTHMAQTERRPWYIPTWFNREI-VGYTHDSIVTEGEFYTSIALF AY641576_IBV-peafowl_Peafowl/GD/ AVGVPGFVSWVMDGVMFVHMTQTDRRPWYIPTWFNREI-VGYTQDSIITEDSFYTSIALF .:. . . .. : : : .:: NC_002645_HCoV-229E_inf-1_nsp4_7 TSACTRL-EGLGGNNVYCYN-TALMEGSLPYSSIQANAYYKYDNGN-FIKLPEVIAQGFG NC_005831_HCoV-NL63_AmsterdamI_n NSACTRL-EGLGGDNVYCYN-TDLIEGSKPYSTLQPNAYYKYDAKN-YVRFPEILARGFG NC_002306_TGEV_PUR46-MAD_nsp4_74 NTACTTL-TGLGGTIVYCAK-QGLVEGAKLYSDLMPDYYYEHASGN-MVKLPAII-RGLG NC_003436_PEDV_CV777_nsp4_7848.. NSACTTL-SGLGGTAVYCYK-NGLVEGAKLYSELAPHSYYKMVDGN-AVSLPEIISRGFG DQ811787_PRCV_ISU-1_nsp4_7459..8 NTACTTL-TGLGGTIVYCAK-QGLVEGAKLYSDLMPDYYYEHASGN-MVKLPAII-RGLG AY994055_FIPV_79-1146_nsp4_7550. NSACTTL-TGIGGTVVYCAK-QGLVEGAKLYSELLPDYYYEHASGN-MVKIPAII-RSFG NC_009657_BtCoV-G1_BtCoV/512/200 NSACTTL-SGIGGRNVYCYR-EGVVDNAKLYSSLLPHSYYRLMDGN-HIVLPEIITRGFG EF203064_Bat-CoV-HKU2_HKU2/GD/43 NSACTNL-EGLGGTRTYCYK-TGLIEGAMTYGDLQHDSYYRLSGDN-YVRLPYVVVQGLG NC_005147_HCoV-OC43_OC43_nsp4_84 SSACTMFTMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL- NC_006577_CoV-HKU1A_N1_nsp4_8720 SSLCTMFKRGDGTPHPYCYS-DGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGI- AY884001_CoV-HKU1B_N2_nsp4_8624. SSLCTMFKRGDGTPHPYCYS-DGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGI- DQ339101_CoV-HKU1C_N5_nsp4_8564. SSLCTMFKRGDGTPHPYCYT-DGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGI- NC_003045_BCoV_BCoV-ENT_nsp4_846 SSACTMFAMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL- NC_001846_MHV_MHV-A59_nsp4_8721. SSLCTMLAHADGTPHPYCYT-GGVMHNASLYSSLAPHVRYNLASSNGYIRFPEVVSEGI- NC_007732_PHEV_VW572_nsp4_8461.. SSACTMFAMADGRPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL- EF424621_AntelopeCoV_US/OH1/2003 SSACTMFAMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL- EF424622_GiCoV_US/OH3-TC/2006_ns SSACTMFAMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL- NC_004718_SARS-human_Tor2_nsp4_8 AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS- AY304488_SARS-civet_SZ16_nsp4_84 AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS- NC_009694_SARS-bat_HKU3-1_nsp4_8 AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS- AY545919_SARS-badger_CFB/SZ/94/0 AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS- NC_009019_Bat-CoV-HKU4_B04f SSECTLFRDAEGNLNPFCYD-PTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIVEST- NC_009020_Bat-CoV-HKU5_LMH3f ASECTLFRDAEGKINPYCYD-PTVLPGASAYDQMKPHVRYDMYDSDMYIKFPEVVFEST- NC_009021_Bat-CoV-HKU9_BF_005I AATCTLFSSASGERMPYCAD-AALIQNASRYDMLKPHVMYPFYEHSGYIRFPEVISAG-- NC_001451_IBV_Beaudette_nsp4_732 SARCLYL-TASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILHTPY- AY646283_IBV-partridge_Partridge ASRCLYL-TSSNTPQLYCFNGDSDAPGALPFASILPHRVYFQPNGVRLIVPQQIMHTPY- AY641576_IBV-peafowl_Peafowl/GD/ SARCLYL-TASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILHIPY- : * : . . :* .: : : * : NC_002645_HCoV-229E_inf-1_nsp4_7 FRTVRTIATKYCRVGECVESNAGVCFGFDK-WFVNDGRVAN--GYVCGTGLWNLVFNILS NC_005831_HCoV-NL63_AmsterdamI_n LRTIRTLATRYCRVGECRDSHKGVCFGFDK-WYVNDGRVDD--GYICGDGLIDLLVNVLS NC_002306_TGEV_PUR46-MAD_nsp4_74 LRFVKTQATTYCRVGECIDSKAGFCFGGDN-WFVYDNEFGN--GYICGNSVLGFFKNVFK NC_003436_PEDV_CV777_nsp4_7848.. IRTIRTKAMTYCRVGQCVQSAEGVCFGADR-FFVYNAESGS--DFVCGTGLFTLLMNVIS DQ811787_PRCV_ISU-1_nsp4_7459..8 LRFVKTQATTYCRVGECIDSKAGFCFGGDN-WFVYDNEFGN--GYICGNSVLGFFKNVFK AY994055_FIPV_79-1146_nsp4_7550. LRFVKTQATTYCRVGECTESQAGFCFGGDN-WFVYDKEFGD--GYICGSSTLGFFKNVFA NC_009657_BtCoV-G1_BtCoV/512/200 IRTIKTQAMTYCRTGECIDSQAGVCVGLDR-FFVYSKTPGS--DYVCGTGFFSLLFNVIG EF203064_Bat-CoV-HKU2_HKU2/GD/43 FRAVRTQATTYCRVGECVDSKAGMCFGADR-WMVYSNDIGS--DFICGSSLVDLLRNILS NC_005147_HCoV-OC43_OC43_nsp4_84 VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK NC_006577_CoV-HKU1A_N1_nsp4_8720 VRIVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFS AY884001_CoV-HKU1B_N2_nsp4_8624. VRIVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFS DQ339101_CoV-HKU1C_N5_nsp4_8564. VRIVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDFFDLFYQFFS NC_003045_BCoV_BCoV-ENT_nsp4_846 VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK NC_001846_MHV_MHV-A59_nsp4_8721. VRVVRTRSMTYCRVGLCEEAEEGICFNFNRSWVLNNPYYRAMPGTFCGRNAFDLIHQVLG NC_007732_PHEV_VW572_nsp4_8461.. VRIVRTRSMSYCRVGLCEDADEGVCFNFNGSWVLNNEYYRSLPGTFCGRDVFDLIYQLFK EF424621_AntelopeCoV_US/OH1/2003 VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK EF424622_GiCoV_US/OH3-TC/2006_ns VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK NC_004718_SARS-human_Tor2_nsp4_8 VRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFT AY304488_SARS-civet_SZ16_nsp4_84 VRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFT NC_009694_SARS-bat_HKU3-1_nsp4_8 VRVVTTFDAEYCRHGTCERSEVGVCLSTSGRWVLNNEHYRALPGVFCGVDAMNLIANIFT AY545919_SARS-badger_CFB/SZ/94/0 VRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFT NC_009019_Bat-CoV-HKU4_B04f LRITKTLATQYCRFGSCEESAAGVCISTNGSWALYNQNYSTRPGIYCGDDYFDIVRRLAI NC_009020_Bat-CoV-HKU5_LMH3f LRITKTLATRYCRFGSCEDANEGVCITTNGSWAIYNDHYANKPGVYCGDNYFDIVRRLGL NC_009021_Bat-CoV-HKU9_BF_005I VHIVRTMAMEYCKVGRCDVSEAGLCMSLQPRWVVNNAYFRQQSGVYCGTSAFDLFMNMLL NC_001451_IBV_Beaudette_nsp4_732 --VVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGSTVRELMFSMVS AY646283_IBV-partridge_Partridge --IVRLVSDSYCRGSVCEYTKPGYCVSLNSQWVLFNDEYTSKPGVFCGSTVRELLFNMVS AY641576_IBV-peafowl_Peafowl/GD/ --IVKFVSDSYCRGSVCEYTKPGYCVSLDSQWVLFNDEYISEPGVFCGSTVRELMFNMVS **. . * : * *. . : : . . ** :. . NC_002645_HCoV-229E_inf-1_nsp4_7 MFSSSFSVAAMSGQILLNCALGAFAIFCCFLVTKFRRMFGDLSVGVCTVVVAVLLNNVS- NC_005831_HCoV-NL63_AmsterdamI_n IFSSSFSVVAMSGHMLFNFLFAAFITFLCFLVTKFKRVFGDLSYGVFTVVCATLINNIS- NC_002306_TGEV_PUR46-MAD_nsp4_74 LFNSNMSVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGDCTFLIVMIIVTLVVNNVS- NC_003436_PEDV_CV777_nsp4_7848.. VFSKTVPVTVLSGQILFNCIIAFVAVAVCFLFTKFKRMFGDMSVGVFTVGACTLLNNVS- DQ811787_PRCV_ISU-1_nsp4_7459..8 LFNSNMSVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGDCTFLIVMIIVTLVVNNVS- AY994055_FIPV_79-1146_nsp4_7550. LFNSNMSVVATSGAMLANIVIACLAIAVCYGVLKFKKIFGDCTLLVVMIIVTLVVNNVS- NC_009657_BtCoV-G1_BtCoV/512/200 MFSNSIPVTVMSGQILLNCVVAFTAVMACFAFTKFKRLFGDMSFGVLSVGLCTVVNNLS- EF203064_Bat-CoV-HKU2_HKU2/GD/43 VFNYNFSTMIMSGQVIFNCVLACVVVFGCYFVMKFRRVFGDMSLAVFTVCAAVVVNNLS- NC_005147_HCoV-OC43_OC43_nsp4_84 GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVNVIVWCVNFMML NC_006577_CoV-HKU1A_N1_nsp4_8720 SLIRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVVVWCINFLML AY884001_CoV-HKU1B_N2_nsp4_8624. SLIRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLML DQ339101_CoV-HKU1C_N5_nsp4_8564. SLIRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLML NC_003045_BCoV_BCoV-ENT_nsp4_846 GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMML NC_001846_MHV_MHV-A59_nsp4_8721. GLVRPIDFFALTASSVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLML NC_007732_PHEV_VW572_nsp4_8461.. GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVNVVVWCVNFMML EF424621_AntelopeCoV_US/OH1/2003 GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMML EF424622_GiCoV_US/OH3-TC/2006_ns GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMML NC_004718_SARS-human_Tor2_nsp4_8 PLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTIL AY304488_SARS-civet_SZ16_nsp4_84 PLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANALLFLMSFTIL NC_009694_SARS-bat_HKU3-1_nsp4_8 PLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANALLFLMSFTIL AY545919_SARS-badger_CFB/SZ/94/0 PLVQPVGALDVSASAVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANALLFLMSFTIL NC_009019_Bat-CoV-HKU4_B04f SLFQPVTYFQLSTSLAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAALLNSLCL NC_009020_Bat-CoV-HKU5_LMH3f SLFQPVTYFQLSTSLALGVMLCIFLTIAFYYVNKVKRALADYTQCAVVAVAAALLNSLCL NC_009021_Bat-CoV-HKU9_BF_005I PIFTPVGAVDITTSILMGALLAVVVSMSLYYLLRFRRAFGDYSGVIFTNILAFVLNVIVL NC_001451_IBV_Beaudette_nsp4_732 TFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKFQGVFKAYATTVFITMLVWVINAFIL AY646283_IBV-partridge_Partridge TFFTGVNP-NIYMQLATMFLILVAVVLVFAMVIKFQGVFKAYATTVFVIMLVWLINAFVL AY641576_IBV-peafowl_Peafowl/GD/ TFFTGVNP-NIYIQLATMFLILVVIVLIFAMVIKFQGVFKAYATIVFTIMLVWVINAFVL : . . . ... : :. NC_002645_HCoV-229E_inf-1_nsp4_7 YIVTQNLVTMIAYAILYFFATRSLRY--AWIWCAAYLIAYISFAPWWLCAWYFLAMLTGL NC_005831_HCoV-NL63_AmsterdamI_n YVVTQNLFFMLLYAILYFVFTRTVRY--AWIWHIAYIVAYFLLIPWWLLTWFSFAAFLEL NC_002306_TGEV_PUR46-MAD_nsp4_74 YFVTQNTFFMIIYAIVYYFITRKLAY--PGILDAGFIIAYINMAPWYVITAYILVFLYDS NC_003436_PEDV_CV777_nsp4_7848.. YIVTQNTLGMLGYATLYFLCTKGVRY--MWIWHLGFLISYILIAPWWVLMVYAFSAIFEF DQ811787_PRCV_ISU-1_nsp4_7459..8 YFVTQNTFFMIIYTIVYYFITRKIAY--PGIFDAGFIIAYINMAPWYVITTYVLVFLYDS AY994055_FIPV_79-1146_nsp4_7550. YFVTQNTFFMIVYAIIYYFTTRKLAY--PGVLDAGFIIAYLNMAPWYVLVLYIMVFLYDS NC_009657_BtCoV-G1_BtCoV/512/200 YVVTQNSIGMLAYATLYFLCTKGVRY--SWVWHVGFAISYCFLAPWWVVLAYLICALLEF EF203064_Bat-CoV-HKU2_HKU2/GD/43 YFVSLNYVGMVVYSFLYFISTRGLKY--CFIWDVSYVVAYCLLAPWWLLTWYICAALIGL NC_005147_HCoV-OC43_OC43_nsp4_84 FVFQVYPILSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYIAVVVSNH NC_006577_CoV-HKU1A_N1_nsp4_8720 FVFQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANH AY884001_CoV-HKU1B_N2_nsp4_8624. FVFQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANH DQ339101_CoV-HKU1C_N5_nsp4_8564. FVFQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANH NC_003045_BCoV_BCoV-ENT_nsp4_846 FVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNH NC_001846_MHV_MHV-A59_nsp4_8721. FVFQVYPTLSCLYACFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNH NC_007732_PHEV_VW572_nsp4_8461.. FVFQVYPTLSCVYAICYFYATLYFPYEISVIMHLQWLVMYGTIMPLWFCLLYISVVFSNH EF424621_AntelopeCoV_US/OH1/2003 FVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNH EF424622_GiCoV_US/OH3-TC/2006_ns FVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNH NC_004718_SARS-human_Tor2_nsp4_8 CLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH AY304488_SARS-civet_SZ16_nsp4_84 CLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH NC_009694_SARS-bat_HKU3-1_nsp4_8 CLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH AY545919_SARS-badger_CFB/SZ/94/0 CLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH NC_009019_Bat-CoV-HKU4_B04f CFIVANPLLVAPYTAMYYYATFYLTGEPAFIMHISWYVMFGAVVPIWMLASYTVGVMLRH NC_009020_Bat-CoV-HKU5_LMH3f CFVVSNPLLVLPYTALYYYATFYLTGEPAFVMHVSWFVMFGTVVPIWMVFAYIVGVCLRH NC_009021_Bat-CoV-HKU9_BF_005I CLEGPYPMLPSIYAMVFLYATCYFGSDIACMMHVSFLIMFAGVVPLWVTVLYIVVVLSRH NC_001451_IBV_Beaudette_nsp4_732 CVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLVFTFGLIVPTWLACCYLGFIIYMY AY646283_IBV-partridge_Partridge CVHSYNSVLAIILLVLYCYVSLATSRNTAIVMHCWLVFTFGLIVPNWIVCVYLGFILYMY AY641576_IBV-peafowl_Peafowl/GD/ CVHSYNSVLAVILLVLYCYASLVTSRNTAIIMHCWLVFTFGLIVPTWLACCYLGFILYMY . : : : : . * :. : NC_002645_HCoV-229E_inf-1_nsp4_7 LP---SLLKL--KVSTNLFEGDKFVGTFESAAAGTFVIDMRSYEKLANS--ISPEKLKSY NC_005831_HCoV-NL63_AmsterdamI_n LP---NVFKL--KISTQLFEGDKFIGTFESAAAGTFVLDMRSYERLINT--ISPEKLKNY NC_002306_TGEV_PUR46-MAD_nsp4_74 LP---SLFKL--KVSTNLFEGDKFVGNFESAAMGTFVIDMRSYETIVNS--TSIARIKSY NC_003436_PEDV_CV777_nsp4_7848.. MP---NLFKL--KVSTQLFEGDKFVGSFENAAAGTFVLDMHAYERLANS--ISTEKLRQY DQ811787_PRCV_ISU-1_nsp4_7459..8 LP---SLFKL--KVSTNLFEGDKFVGNFESAAMGTFVIDMRSYETIVNS--IPIDRIKSY AY994055_FIPV_79-1146_nsp4_7550. LP---SLFKL--KVTTNLFEGDKFVGSFESAAMGTFVIDMRSYETLVNS--TSLDRIKSY NC_009657_BtCoV-G1_BtCoV/512/200 LP---NLFKL--KVSTQLFEGDKFVGSFESAASGTFVLDMHSYQKLANS--ISTEKLKQY EF203064_Bat-CoV-HKU2_HKU2/GD/43 IP---NLFKL--KVSTTLFEGTKFVGTFDAASVGTFVIDARSYERLINS--TSIEKIKQY NC_005147_HCoV-OC43_OC43_nsp4_84 AF---WVFSYCRKLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY NC_006577_CoV-HKU1A_N1_nsp4_8720 VL---WLFSYCRKIGVNVCSD----STFEETSLTTFMITKDSYCRLKNS--VSDVAYNRY AY884001_CoV-HKU1B_N2_nsp4_8624. VL---WLFSYCRKIGVNVCND----STFEETSLTTFMITKDSYCRLKNS--VSDVAYNRY DQ339101_CoV-HKU1C_N5_nsp4_8564. VL---WLFSYCRKIGVNVCSD----STFEETSLTTFMITKDSYCRLKNS--VSDVAYNRY NC_003045_BCoV_BCoV-ENT_nsp4_846 AF---WVFAYCRRLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY NC_001846_MHV_MHV-A59_nsp4_8721. AL---WLFSYCRKIGTEVRSD----GTFEEMALTTFMITKESYCKLKNS--VSDVAFNRY NC_007732_PHEV_VW572_nsp4_8461.. AL---WVFSYCRQLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY EF424621_AntelopeCoV_US/OH1/2003 AF---WVFAYCRRLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY EF424622_GiCoV_US/OH3-TC/2006_ns AF---WVFAYCRRLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY NC_004718_SARS-human_Tor2_nsp4_8 CH---WFFNNY-LRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY AY304488_SARS-civet_SZ16_nsp4_84 CH---WFFNNY-LRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY NC_009694_SARS-bat_HKU3-1_nsp4_8 FH---WFFSNY-LKKRVMFNGVTF-STFEEAALCTFLLNKEMYLRLRSETLLPLTQYNRY AY545919_SARS-badger_CFB/SZ/94/0 CH---WFFNNY-LRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY NC_009019_Bat-CoV-HKU4_B04f LF---WVLAYFSKKHVDVFTDGKLNCSFQDAASNIFVIGKDTYVALRNA--ITQDSFVRY NC_009020_Bat-CoV-HKU5_LMH3f LL---WVMAYFSKKHVEVFTDGKLNCSFQDAAANIFVINKDTYVALRNS--ITQDSYNRY NC_009021_Bat-CoV-HKU9_BF_005I IL---WFASLCTKRTVQV--GDLAFHSFQDAALQTFMLDKEVFLRLKRE--ISSDAYFKY NC_001451_IBV_Beaudette_nsp4_732 TPLFLWCYGTT-KNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFVKLTNE--IG-DKFEAY AY646283_IBV-partridge_Partridge TPLFLWCYGTT-KNSRKLYEGNEFVGNYDLAAKSTFVVRGPEFVKLTNE--LG-DKFESY AY641576_IBV-peafowl_Peafowl/GD/ TPLVFWCYGTT-KNTRKLYDGNEFVGNYDLAAKSTFVIRGTEFVKLTNE--IG-DKFEAY : . .:: : *:: : : * NC_002645_HCoV-229E_inf-1_nsp4_7 AASYNRYKYYSGNANEADYRCACYAYLAKAMLDFS-RDHNDILYTPPTVSYGST-LQ NC_005831_HCoV-NL63_AmsterdamI_n AASYNKYKYYSGSASEADYRCACYAHLAKAMLDYA-KDHNDMLYSPPTISYNST-LQ NC_002306_TGEV_PUR46-MAD_nsp4_74 ANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS-VNRTDMLYTPPTVSVNST-LQ NC_003436_PEDV_CV777_nsp4_7848.. ASTYNKYKYYSGSASEADYRLACFAHLAKAMMDYA-SNHNDTLYTPPTVSYNST-LQ DQ811787_PRCV_ISU-1_nsp4_7459..8 ANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS-VNRTDMLYTPPTVSVNST-LQ AY994055_FIPV_79-1146_nsp4_7550. ANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS-VSRNDMLYTPPTVSVNST-LQ NC_009657_BtCoV-G1_BtCoV/512/200 CASYNRYKYYSGSASEADYRLACFAHLAKAMSDFA-NDHMDKLYTPPTVSYNST-LQ EF203064_Bat-CoV-HKU2_HKU2/GD/43 ASTFNKYKYYSGSANEADYRCACYAHLAKALIDFS-TTRQDTLYTPPTVSINST-LQ NC_005147_HCoV-OC43_OC43_nsp4_84 LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ NC_006577_CoV-HKU1A_N1_nsp4_8720 LSLYNKYRYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQ AY884001_CoV-HKU1B_N2_nsp4_8624. LSLYNKYRYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQ DQ339101_CoV-HKU1C_N5_nsp4_8564. LSLYNKYRYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQ NC_003045_BCoV_BCoV-ENT_nsp4_846 LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ NC_001846_MHV_MHV-A59_nsp4_8721. LSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQ NC_007732_PHEV_VW572_nsp4_8461.. LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ EF424621_AntelopeCoV_US/OH1/2003 LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ EF424622_GiCoV_US/OH3-TC/2006_ns LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ NC_004718_SARS-human_Tor2_nsp4_8 LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ AY304488_SARS-civet_SZ16_nsp4_84 LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ NC_009694_SARS-bat_HKU3-1_nsp4_8 LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ AY545919_SARS-badger_CFB/SZ/94/0 LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ NC_009019_Bat-CoV-HKU4_B04f LSLFNKYKYYSGAMDTASYREACAAHLCKALQTYS-ETGSDILYQPPNCSVTSSVLQ NC_009020_Bat-CoV-HKU5_LMH3f LSMFNKYKYYSGAMDTASYREASAAHLCKALQVYS-ETGSDVLFQPPNCSVTSSVLQ NC_009021_Bat-CoV-HKU9_BF_005I LAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYS-NGGGDTIYQPPRCSVASAALQ NC_001451_IBV_Beaudette_nsp4_732 LSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYR-NSGVEIVYTPPRYSIGVSRLQ AY646283_IBV-partridge_Partridge LSAYARLKYYSGTGSEQDYLQACRAWLAYALDQFR-SSGVEVVYTPPRYSIGVSRLQ AY641576_IBV-peafowl_Peafowl/GD/ LSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYR-NSGVEVVYTPPRYSIGVSRLQ : . .*::* . * *. . * *: : : :: ** * : **