>NC_002645_HCoV-229E_inf-1_nsp4_7745..9187_1443bp_481aa
-------GDAGHSLTWLW---LLCGLVCLIQFYLCFF-MPYFMYDIVSSFEG------YD
FKYIENGQLKNFEAPLKCVRNVFENFEDWHYAKFGFT-PLNKQSCPIVVGVS---EIVNT
VAGIPSNVYL-VGKTLI----------FTLQAAFGNAG-VCYDIFGVTTPEK-----CIF
TSACTRL-EGLGGNNVYCYN-TALMEGSLPYSSIQANAYYKYDNGN-FIKLPEVIAQGFG
FRTVRTIATKYCRVGECVESNAGVCFGFDK-WFVNDGRVAN--GYVCGTGLWNLVFNILS
MFSSSFSVAAMSGQILLNCALGAFAIFCCFLVTKFRRMFGDLSVGVCTVVVAVLLNNVS-
YIVTQNLVTMIAYAILYFFATRSLRY--AWIWCAAYLIAYISFAPWWLCAWYFLAMLTGL
LP---SLLKL--KVSTNLFEGDKFVGTFESAAAGTFVIDMRSYEKLANS--ISPEKLKSY
AASYNRYKYYSGNANEADYRCACYAYLAKAMLDFS-RDHNDILYTPPTVSYGST-LQ
>NC_005831_HCoV-NL63_AmsterdamI_nsp4_7673..9103_1431bp_477aa
--------GFKRTYNFLW---YVCLFVVALFIGVSFID---YTTTVTSFHG-------YD
FKYIENGQLKVFEAPLHCVRNVFDNFNQWHEAKFGVV-TTNSDKCPIVVGVS---ERINV
VPGVPTNVYL-VGKTLV----------FTLQAAFGNTG-VCYDFDGVTTSDK-----CIF
NSACTRL-EGLGGDNVYCYN-TDLIEGSKPYSTLQPNAYYKYDAKN-YVRFPEILARGFG
LRTIRTLATRYCRVGECRDSHKGVCFGFDK-WYVNDGRVDD--GYICGDGLIDLLVNVLS
IFSSSFSVVAMSGHMLFNFLFAAFITFLCFLVTKFKRVFGDLSYGVFTVVCATLINNIS-
YVVTQNLFFMLLYAILYFVFTRTVRY--AWIWHIAYIVAYFLLIPWWLLTWFSFAAFLEL
LP---NVFKL--KISTQLFEGDKFIGTFESAAAGTFVLDMRSYERLINT--ISPEKLKNY
AASYNKYKYYSGSASEADYRCACYAHLAKAMLDYA-KDHNDMLYSPPTISYNST-LQ
>NC_002306_TGEV_PUR46-MAD_nsp4_7479..8948_1470bp_490aa
---SGFFDVITQLKQI-----VILVFVFIFICGLCSVYSVATQSYIESAEG-------YD
YMVIKNGIVQPFDDTISCVHNTYKGFGDWFKAKYGFI-PTFGKSCPIVVGTVFDLENMRP
IPDVPAYVSI-VGRSLV----------FAINAAFGVTN-MCYDHTGNAVSKDSYFDTCVF
NTACTTL-TGLGGTIVYCAK-QGLVEGAKLYSDLMPDYYYEHASGN-MVKLPAII-RGLG
LRFVKTQATTYCRVGECIDSKAGFCFGGDN-WFVYDNEFGN--GYICGNSVLGFFKNVFK
LFNSNMSVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGDCTFLIVMIIVTLVVNNVS-
YFVTQNTFFMIIYAIVYYFITRKLAY--PGILDAGFIIAYINMAPWYVITAYILVFLYDS
LP---SLFKL--KVSTNLFEGDKFVGNFESAAMGTFVIDMRSYETIVNS--TSIARIKSY
ANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS-VNRTDMLYTPPTVSVNST-LQ
>NC_003436_PEDV_CV777_nsp4_7848..9287_1440bp_480aa
-----GLPSFSKVKKFFW---FLCLFIVAAFFALSFLDFSTQVSSDSD----------YD
FKYIESGQLKTFDNPLSCVHNVFINFDQWHDAKFGFT-PVNNPSCPIVVGVS---DEART
VPGIPAGVYL-AGKTLV----------FAINTIFGTSG-LCFDASGVADKGA-----CIF
NSACTTL-SGLGGTAVYCYK-NGLVEGAKLYSELAPHSYYKMVDGN-AVSLPEIISRGFG
IRTIRTKAMTYCRVGQCVQSAEGVCFGADR-FFVYNAESGS--DFVCGTGLFTLLMNVIS
VFSKTVPVTVLSGQILFNCIIAFVAVAVCFLFTKFKRMFGDMSVGVFTVGACTLLNNVS-
YIVTQNTLGMLGYATLYFLCTKGVRY--MWIWHLGFLISYILIAPWWVLMVYAFSAIFEF
MP---NLFKL--KVSTQLFEGDKFVGSFENAAAGTFVLDMHAYERLANS--ISTEKLRQY
ASTYNKYKYYSGSASEADYRLACFAHLAKAMMDYA-SNHNDTLYTPPTVSYNST-LQ
>DQ811787_PRCV_ISU-1_nsp4_7459..8928_1470bp_490aa
---SGFFDVITQLKQI-----VILVFVFIFICGLCSVYSVATQSYIESAEG-------YD
YMVIKNGIVQPFDDTISCVHNTYKGFSDWFKAKYGFI-PTFGKSCPIVVGTVFDLENMRP
IPDVPAYVSI-VGRSLV----------FAINAAFGVTN-MCYDHTGNAVSKDSYFDTCVF
NTACTTL-TGLGGTIVYCAK-QGLVEGAKLYSDLMPDYYYEHASGN-MVKLPAII-RGLG
LRFVKTQATTYCRVGECIDSKAGFCFGGDN-WFVYDNEFGN--GYICGNSVLGFFKNVFK
LFNSNMSVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGDCTFLIVMIIVTLVVNNVS-
YFVTQNTFFMIIYTIVYYFITRKIAY--PGIFDAGFIIAYINMAPWYVITTYVLVFLYDS
LP---SLFKL--KVSTNLFEGDKFVGNFESAAMGTFVIDMRSYETIVNS--IPIDRIKSY
ANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS-VNRTDMLYTPPTVSVNST-LQ
>AY994055_FIPV_79-1146_nsp4_7550..9019_1470bp_490aa
---SGFFDVLKQLKQLFW-----CLVLFITLYGLCSVYSVATQSYIDSAEG-------YD
YMVIKNGVVQSFDDSINCVHNTYKGFAVWFKAKHGFV-PTFDKSCPIVLGTVFDLGNMRP
IPDVPAYVAL-VGRSLV----------FAINAAFGVTN-VCYDHTGAAVSKNSYFDTCVF
NSACTTL-TGIGGTVVYCAK-QGLVEGAKLYSELLPDYYYEHASGN-MVKIPAII-RSFG
LRFVKTQATTYCRVGECTESQAGFCFGGDN-WFVYDKEFGD--GYICGSSTLGFFKNVFA
LFNSNMSVVATSGAMLANIVIACLAIAVCYGVLKFKKIFGDCTLLVVMIIVTLVVNNVS-
YFVTQNTFFMIVYAIIYYFTTRKLAY--PGVLDAGFIIAYLNMAPWYVLVLYIMVFLYDS
LP---SLFKL--KVTTNLFEGDKFVGSFESAAMGTFVIDMRSYETLVNS--TSLDRIKSY
ANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYS-VSRNDMLYTPPTVSVNST-LQ
>NC_009657_BtCoV-G1_BtCoV/512/2005_nsp4_7887..9329_1443bp_481aa
----GLPSLFTRLYSFFW---HLCVLIVVLFVATSLLDFSAQVTSDTQ----------YD
FKYIENGVLKVFEKPLDCVHNAFVNFNEWHNAKFGSI-PTNSRRCPIVVGTS---DEVRY
IPGVPAGVFL-YGKSLI----------FAMSTIFGTSG-LCFDDRGLTDPDS-----CIF
NSACTTL-SGIGGRNVYCYR-EGVVDNAKLYSSLLPHSYYRLMDGN-HIVLPEIITRGFG
IRTIKTQAMTYCRTGECIDSQAGVCVGLDR-FFVYSKTPGS--DYVCGTGFFSLLFNVIG
MFSNSIPVTVMSGQILLNCVVAFTAVMACFAFTKFKRLFGDMSFGVLSVGLCTVVNNLS-
YVVTQNSIGMLAYATLYFLCTKGVRY--SWVWHVGFAISYCFLAPWWVVLAYLICALLEF
LP---NLFKL--KVSTQLFEGDKFVGSFESAASGTFVLDMHSYQKLANS--ISTEKLKQY
CASYNRYKYYSGSASEADYRLACFAHLAKAMSDFA-NDHMDKLYTPPTVSYNST-LQ
>EF203064_Bat-CoV-HKU2_HKU2/GD/430/2006_nsp4_7686..9119_1434bp_478aa
-------GKLSSMWKNFW---YACGAILALFVLLNCVGFTEYASSLPG----------YD
FKYIEDGQLKPFVNGLYCVRNTFDTFMDWHAQKFGFK-PSNSDKCPIVVGAS---DSGRV
VPGVASDVYL-LGKTLI----------FTLKTVFGSAG-HCYDVNGIADGDK-----CLF
NSACTNL-EGLGGTRTYCYK-TGLIEGAMTYGDLQHDSYYRLSGDN-YVRLPYVVVQGLG
FRAVRTQATTYCRVGECVDSKAGMCFGADR-WMVYSNDIGS--DFICGSSLVDLLRNILS
VFNYNFSTMIMSGQVIFNCVLACVVVFGCYFVMKFRRVFGDMSLAVFTVCAAVVVNNLS-
YFVSLNYVGMVVYSFLYFISTRGLKY--CFIWDVSYVVAYCLLAPWWLLTWYICAALIGL
IP---NLFKL--KVSTTLFEGTKFVGTFDAASVGTFVIDARSYERLINS--TSIEKIKQY
ASTFNKYKYYSGSANEADYRCACYAHLAKALIDFS-TTRQDTLYTPPTVSINST-LQ
>NC_005147_HCoV-OC43_OC43_nsp4_8461..9948_1488bp_496aa
-----------AVFSYFV---YVCFVLSLVCFIGLWCLMPTYTVHKSDFQLP----VYAS
YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVI-DQDFGST
VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL
SSACTMFTMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL-
VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK
GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVNVIVWCVNFMML
FVFQVYPILSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYIAVVVSNH
AF---WVFSYCRKLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ
>NC_006577_CoV-HKU1A_N1_nsp4_8720..10207_1488bp_496aa
-------VVLSNLL-------YILFFVSLICFILLWALLPTYSVYKSDIHLP----AYAS
FKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVVAVM-DEDIGST
MFNVPTKVLR-HGFHVL----------HFLTYAFASDSVQCYTPHIQISYNDFYASGCVL
SSLCTMFKRGDGTPHPYCYS-DGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGI-
VRIVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFS
SLIRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVVVWCINFLML
FVFQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANH
VL---WLFSYCRKIGVNVCSD----STFEETSLTTFMITKDSYCRLKNS--VSDVAYNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQ
>AY884001_CoV-HKU1B_N2_nsp4_8624..10111_1488bp_496aa
-------VVLSNLL-------YILFFISLICFILLWALLPTYSVYKSDIHLP----AYAS
FKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSFYYHNSMDCPIVVAVM-DEDIGST
MFNVPTKVLR-HGFHVL----------HFLTYAFASDSVQCYTPHIQISYNDFYASGCVL
SSLCTMFKRGDGTPHPYCYS-DGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGI-
VRIVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFS
SLIRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLML
FVFQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANH
VL---WLFSYCRKIGVNVCND----STFEETSLTTFMITKDSYCRLKNS--VSDVAYNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQ
>DQ339101_CoV-HKU1C_N5_nsp4_8564..10051_1488bp_496aa
-------VVLSNLL-------YILFFISLICFILLWALLPTYSVYKSDIHLP----AYAS
FKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVVAVM-DEDIGST
MFNVPTKVLR-YGFHVL----------HFLTYAFASDSVQCYTPHIQISYNDFYASGCVL
SSLCTMFKRGDGTPHPYCYT-DGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGI-
VRIVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDFFDLFYQFFS
SLIRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLML
FVFQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANH
VL---WLFSYCRKIGVNVCSD----STFEETSLTTFMITKDSYCRLKNS--VSDVAYNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQ
>NC_003045_BCoV_BCoV-ENT_nsp4_8461..9948_1488bp_496aa
-----------AVFSYFV---YVCFLLSLVCFIGLWCLMPTYTVHKSDFQLP----VYAS
YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVV-DQDLGST
VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL
SSACTMFAMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL-
VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK
GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMML
FVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNH
AF---WVFAYCRRLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ
>NC_001846_MHV_MHV-A59_nsp4_8721..10208_1488bp_496aa
-------AVFSRMLQW-------LFVANLICFIVLWALMPTYAVHKSDMQLP----LYAS
FKVIDNGVLRDVSVTDACFANKFNQFDQWYESTFGLAYYRNSKACPVVVAVI-DQDIGHT
LFNVPTTVLR-YGFHVL----------HFITHAFATDSVQCYTPHMQIPYDNFYASGCVL
SSLCTMLAHADGTPHPYCYT-GGVMHNASLYSSLAPHVRYNLASSNGYIRFPEVVSEGI-
VRVVRTRSMTYCRVGLCEEAEEGICFNFNRSWVLNNPYYRAMPGTFCGRNAFDLIHQVLG
GLVRPIDFFALTASSVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLML
FVFQVYPTLSCLYACFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNH
AL---WLFSYCRKIGTEVRSD----GTFEEMALTTFMITKESYCKLKNS--VSDVAFNRY
LSLYNKYRYFSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQ
>NC_007732_PHEV_VW572_nsp4_8461..9948_1488bp_496aa
-----------AVFSYFV---YVCFVLSLICFIGLWCLMPTYAVYKSDFQLP----VYAS
YKVLDNGVIRDISVEDVCFANKFEQFDQWYESTFGLNYYSNNMACPIVVAVI-DQDIGST
VFNVPTKVLR-YGYHVL----------HFITHAFSADGVQCYTPHSQISYSTFYASGCVL
SSACTMFAMADGRPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL-
VRIVRTRSMSYCRVGLCEDADEGVCFNFNGSWVLNNEYYRSLPGTFCGRDVFDLIYQLFK
GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVNVVVWCVNFMML
FVFQVYPTLSCVYAICYFYATLYFPYEISVIMHLQWLVMYGTIMPLWFCLLYISVVFSNH
AL---WVFSYCRQLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ
>EF424621_AntelopeCoV_US/OH1/2003WD1418_nsp4_8446..9933_1488bp_496aa
-----------AVFSYFV---YVCFLLSLVCFIGLWCLMPTYTVQKSDFQLP----VYAS
YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVV-DQDFGST
VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL
SSACTMFAMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL-
VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK
GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMML
FVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNH
AF---WVFAYCRRLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ
>EF424622_GiCoV_US/OH3-TC/2006_nsp4_8445..9932_1488bp_496aa
-----------AVFSYFV---YVCFLLSLVCFIGLWCLMPTYTVQKSDFQLP----VYAS
YKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVV-DQDFGST
VFNVPTKVLR-YGYHVL----------HFITHALSADGVQCYTPHSQISYSNFYASGCVL
SSACTMFAMADGSPQPYCYT-EGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVLREGL-
VRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFK
GLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMML
FVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNH
AF---WVFAYCRRLGTSVRSD----GTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRY
LSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQ
>NC_004718_SARS-human_Tor2_nsp4_8485..9984_1500bp_500aa
-------KIVSTCFKLM----LKATLLCVLAALVCYIVMPVHTLSIHDGYTN----EIIG
YKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVAAII-TREIGFI
VPGLPGTVLRAINGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL
AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS-
VRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFT
PLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTIL
CLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH
CH---WFFNNY-LRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY
LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ
>AY304488_SARS-civet_SZ16_nsp4_8470..9969_1500bp_500aa
-------KIVSTWFKLM----LKATLLCVLAALVCYIVMPVHTLSIHDGYTN----EIIG
YKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVAAII-TREIGFI
VPGLPGTVLRAINGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL
AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS-
VRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFT
PLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANALLFLMSFTIL
CLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH
CH---WFFNNY-LRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY
LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ
>NC_009694_SARS-bat_HKU3-1_nsp4_8464..9963_1500bp_500aa
-------KVVSTWFKLL----LKVTLLCVLAALFCYVIMPVHSLSVHDGYTN----EIIG
YKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRGGS--YRNDKNCPVVAAII-TREIGFI
VPGLPGTVLRALNGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL
AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS-
VRVVTTFDAEYCRHGTCERSEVGVCLSTSGRWVLNNEHYRALPGVFCGVDAMNLIANIFT
PLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANALLFLMSFTIL
CLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH
FH---WFFSNY-LKKRVMFNGVTF-STFEEAALCTFLLNKEMYLRLRSETLLPLTQYNRY
LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ
>AY545919_SARS-badger_CFB/SZ/94/03_nsp4_8464..9963_1500bp_500aa
-------KIVSTWFKLM----LKATLLCVLAALVCYIVMPVHTLSIHDGYTN----EIIG
YKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVAAII-TREIGFI
VPGLPGTVLRAINGDFL----------HFLPRVFSAVGNICYTPSKLIEYSDFATSACVL
AAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGS-
VRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFT
PLVQPVGALDVSASAVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANALLFLMSFTIL
CLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKH
CH---WFFNNY-LRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY
LALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQ
>NC_009019_Bat-CoV-HKU4_B04f HKU41_nsp4_8619..10139_1521bp_507aa
----GAPSWLLRVRDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDD----RILT
YKVIENGIVRDIAPNDVCFANKYGHFSKWFNENHGGV-YRNSMDCPITIAVI-AGVAGAR
VANVPANLAW-VGKQIV----------LFVSRVFANTN-VCFTPINEIPYDTFSDSGCVL
SSECTLFRDAEGNLNPFCYD-PTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIVEST-
LRITKTLATQYCRFGSCEESAAGVCISTNGSWALYNQNYSTRPGIYCGDDYFDIVRRLAI
SLFQPVTYFQLSTSLAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAALLNSLCL
CFIVANPLLVAPYTAMYYYATFYLTGEPAFIMHISWYVMFGAVVPIWMLASYTVGVMLRH
LF---WVLAYFSKKHVDVFTDGKLNCSFQDAASNIFVIGKDTYVALRNA--ITQDSFVRY
LSLFNKYKYYSGAMDTASYREACAAHLCKALQTYS-ETGSDILYQPPNCSVTSSVLQ
>NC_009020_Bat-CoV-HKU5_LMH3f HKU51_nsp4_8751..10274_1524bp_508aa
----GAPKWLLKLRDFTWKSYCVVTLVVFAMAVLSYLCLPAFNMSQVSFHED----RILT
YKVVENGIIRDITPSDTCFANKYQSFSKWFNEHYGGL-FNNDISCPVTVAVI-AGVAGAR
VPNLPANVAW-VGRQIV----------LFVSRVFASSNNVCYTPTAEIPYERFSDSGCVL
ASECTLFRDAEGKINPYCYD-PTVLPGASAYDQMKPHVRYDMYDSDMYIKFPEVVFEST-
LRITKTLATRYCRFGSCEDANEGVCITTNGSWAIYNDHYANKPGVYCGDNYFDIVRRLGL
SLFQPVTYFQLSTSLALGVMLCIFLTIAFYYVNKVKRALADYTQCAVVAVAAALLNSLCL
CFVVSNPLLVLPYTALYYYATFYLTGEPAFVMHVSWFVMFGTVVPIWMVFAYIVGVCLRH
LL---WVMAYFSKKHVEVFTDGKLNCSFQDAAANIFVINKDTYVALRNS--ITQDSYNRY
LSMFNKYKYYSGAMDTASYREASAAHLCKALQVYS-ETGSDVLFQPPNCSVTSSVLQ
>NC_009021_Bat-CoV-HKU9_BF_005I HKU91_nsp4_8056..9537_1482bp_494aa
-----GHRRIVSWRRV-----LIHVFMLLVVLNPQWF-TPWYIMRPIEYNV-------VD
FKVIDNAVIRDITSADQCFANKFSAFENWYSNRYGS--YVNSRGCPMVVGVV-SDIVGSL
VPGLPARFLR-VGTTLL----------PLVNYGLGAVGSVCYTPHYAINYDVFDTSACVL
AATCTLFSSASGERMPYCAD-AALIQNASRYDMLKPHVMYPFYEHSGYIRFPEVISAG--
VHIVRTMAMEYCKVGRCDVSEAGLCMSLQPRWVVNNAYFRQQSGVYCGTSAFDLFMNMLL
PIFTPVGAVDITTSILMGALLAVVVSMSLYYLLRFRRAFGDYSGVIFTNILAFVLNVIVL
CLEGPYPMLPSIYAMVFLYATCYFGSDIACMMHVSFLIMFAGVVPLWVTVLYIVVVLSRH
IL---WFASLCTKRTVQV--GDLAFHSFQDAALQTFMLDKEVFLRLKRE--ISSDAYFKY
LAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYS-NGGGDTIYQPPRCSVASAALQ
>NC_001451_IBV_Beaudette_nsp4_7324..8865_1542bp_514aa
GIVSGTFKCFKSYFKW-----LLIFYILFTACCSGYYYMEVSKSFVHPMYDVNSTLHVEG
FKVIDKGVLREIVPEDTCFSNKFVNFDAFWGRP-----YDNSRNCPIVTAVI--DGDGTV
ATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFNREI-VGYTQDSIITEGSFYTSIALF
SARCLYL-TASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILHTPY-
--VVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGSTVRELMFSMVS
TFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKFQGVFKAYATTVFITMLVWVINAFIL
CVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLVFTFGLIVPTWLACCYLGFIIYMY
TPLFLWCYGTT-KNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFVKLTNE--IG-DKFEAY
LSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYR-NSGVEIVYTPPRYSIGVSRLQ
>AY646283_IBV-partridge_Partridge/GD/S14/2003_nsp4_7177..8718_1542bp_514aa
GVISSTVNRFKSCCKW-----LLVFYLLFTACCLCYYQWEMSKEFAHPMYDVNSTMHVEG
FKVIDKGVLRDIMLEDTCFSNKYVNFDSFWGKP-----YVNSRDCPIVIAII--DGAGTV
AAGVPGFVQWVMDGVMFTHMAQTERRPWYIPTWFNREI-VGYTHDSIVTEGEFYTSIALF
ASRCLYL-TSSNTPQLYCFNGDSDAPGALPFASILPHRVYFQPNGVRLIVPQQIMHTPY-
--IVRLVSDSYCRGSVCEYTKPGYCVSLNSQWVLFNDEYTSKPGVFCGSTVRELLFNMVS
TFFTGVNP-NIYMQLATMFLILVAVVLVFAMVIKFQGVFKAYATTVFVIMLVWLINAFVL
CVHSYNSVLAIILLVLYCYVSLATSRNTAIVMHCWLVFTFGLIVPNWIVCVYLGFILYMY
TPLFLWCYGTT-KNSRKLYEGNEFVGNYDLAAKSTFVVRGPEFVKLTNE--LG-DKFESY
LSAYARLKYYSGTGSEQDYLQACRAWLAYALDQFR-SSGVEVVYTPPRYSIGVSRLQ
>AY641576_IBV-peafowl_Peafowl/GD/KQ6/2003_nsp4_7267..8808_1542bp_514aa
GVINNTFKWFMSCFKW-----LFVFYILFTACCLGYYYMEMNKSFVHPMYDVNSTLHVEG
FKVIDKGVIREIVSEDNCFSNKFVNFDAFWGKS-----YENNKNCPIVTVVI--DGDGTV
AVGVPGFVSWVMDGVMFVHMTQTDRRPWYIPTWFNREI-VGYTQDSIITEDSFYTSIALF
SARCLYL-TASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILHIPY-
--IVKFVSDSYCRGSVCEYTKPGYCVSLDSQWVLFNDEYISEPGVFCGSTVRELMFNMVS
TFFTGVNP-NIYIQLATMFLILVVIVLIFAMVIKFQGVFKAYATIVFTIMLVWVINAFVL
CVHSYNSVLAVILLVLYCYASLVTSRNTAIIMHCWLVFTFGLIVPTWLACCYLGFILYMY
TPLVFWCYGTT-KNTRKLYDGNEFVGNYDLAAKSTFVIRGTEFVKLTNE--IG-DKFEAY
LSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYR-NSGVEVVYTPPRYSIGVSRLQ