LSID Protein-Protein Interactions Project |
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Avian vs. Human Influenza A Mutations
| Protein |
Position |
Avian |
Human |
H1N1 |
HXN2 |
| M1 |
| M1 |
115 |
V |
I |
I |
I |
| M1 |
121 |
T |
A |
A |
A |
| M1 |
137 |
T |
A |
A |
A |
| M2 |
| M2 |
11 |
T |
I |
I |
I |
| M2 |
14 |
G |
E |
E |
E |
| M2 |
20 |
S |
N |
N |
N |
| M2 |
28 |
I |
V |
V |
V |
| M2 |
54 |
R |
LIF |
IL |
LF |
| M2 |
55 |
L |
F |
F |
F |
| M2 |
57 |
Y |
H |
H |
H |
| M2 |
78 |
Q |
KE |
EK |
K |
| M2 |
86 |
V |
A |
A |
A |
| NP |
| NP |
16 |
GS |
D |
D |
D |
| NP |
33 |
V |
I |
I |
I |
| NP |
61 |
I |
L |
L |
L |
| NP |
100 |
R |
VI |
V |
VI |
| NP |
136 |
L |
MI |
I |
MI |
| NP |
214 |
R |
K |
K |
K |
| NP |
283 |
L |
P |
P |
P |
| NP |
305 |
R |
K |
K |
K |
| NP |
313 |
F |
Y |
Y |
Y |
| NP |
357 |
Q |
KR |
KR |
K |
| NP |
375 |
DN |
GEV |
V |
GE |
| NP |
423 |
A |
STP |
T |
SP |
| NS1 |
| NS1 |
22 |
FL |
V |
V |
V |
| NS1 |
60 |
AE |
V |
V |
V |
| NS1 |
81 |
I |
M |
M |
M |
| NS1 |
84 |
VS |
TA |
A |
TA |
| NS1 |
215 |
PSA |
T |
T |
T |
| NS1 |
227 |
E |
R |
R |
R |
| NS2 |
| NS2 |
60 |
S |
NH |
H |
N |
| NS2 |
70 |
S |
G |
G |
G |
| NS2 |
107 |
L |
F |
F |
F |
| PA |
| PA |
28 |
P |
L |
L |
L |
| PA |
55 |
D |
N |
N |
N |
| PA |
57 |
R |
Q |
Q |
Q |
| PA |
65 |
SF |
LP |
PL |
L |
| PA |
66 |
GS |
DE |
ED |
D |
| PA |
100 |
V |
A |
A |
A |
| PA |
225 |
S |
C |
C |
C |
| PA |
268 |
L |
I |
I |
I |
| PA |
321 |
NK |
YST |
STY |
Y |
| PA |
337 |
AT |
S |
S |
S |
| PA |
356 |
K |
R |
R |
R |
| PA |
382 |
E |
D |
D |
D |
| PA |
400 |
PSQ |
L |
L |
L |
| PA |
404 |
A |
S |
S |
S |
| PA |
409 |
S |
N |
N |
N |
| PA |
421 |
S |
IV |
I |
IV |
| PA |
552 |
T |
S |
S |
S |
| PB1 |
| PB1 |
336 |
V |
I |
I |
I |
| PB2 |
| PB2 |
9 |
DE |
NT |
N |
NT |
| PB2 |
44 |
A |
S |
S |
S |
| PB2 |
64 |
M |
T |
T |
T |
| PB2 |
81 |
T |
MV |
VM |
M |
| PB2 |
105 |
TA |
VM |
VM |
VM |
| PB2 |
199 |
A |
S |
S |
S |
| PB2 |
271 |
TI |
A |
A |
A |
| PB2 |
292 |
IV |
T |
T |
T |
| PB2 |
368 |
R |
K |
K |
K |
| PB2 |
475 |
L |
M |
M |
M |
| PB2 |
567 |
DE |
N |
N |
N |
| PB2 |
588 |
AV |
I |
I |
I |
| PB2 |
613 |
VA |
T |
TI |
T |
| PB2 |
627 |
E |
K |
K |
K |
| PB2 |
661 |
A |
T |
T |
T |
| PB2 |
674 |
AS |
T |
T |
T |
| PB2 |
702 |
K |
R |
R |
R |
REFERENCE Miotto, et al. 2010