Influenza A NS1

Sequence Alignments

Structures

Complexes

• NS1 PPI-3-kinase complex 3L4Q, PDBsum 34LQ
• NS1 dsRNA complex 2ZKO, PDBsum 2ZKO
• NS1 CPSF30 complex 2RHK, PDBsum 2RHK

Domains

• NS1 N-term RBD PDB 3M8A, PDBsum 3M8A
• NS1 Effector Domain PDB 3M5R, PDBsum 3M5R
• NS1 Effector W187A mutant 3KWG, PDBsum 3KWG
• NS1 Effector W187Y mutant 3KWI, PDBsum 3KWI
• NS1 Effector W187R mutant NMR 2KKZ, PDBsum 2KKZ
• NS1 Effector Domain 3EE8, PDBsum 3EE8
• NS1 Effector Domain 3EE9, PDBsum 3EE9
• NS1 H5N1 3F5T, PDBsum 3F5T
• NS1 Effector Domain Avian 3D6R, PDBsum 3D6R
• NS1 RBD H5N1 2Z0A, PDBsum 2Z0A
• NS1 Effector Domain 2GX9, PDBsum 2GX9
• NS1 RBD Influenza B 1XEQ, PDBsum 1XEQ
• NS1 RBD NMR 1NS1, PDBsum 1NS1
• NS1 N-Term frag 1AIL, PDBsum 1AIL

Domains and Families

• NCBI Conserved Domains
• PFAM

Protein-protein interactions

• Virus-virus

  Fill soon.

• Virus-host

  Virus Strain	NS1 Sequence	Host	Host Protein	Reference
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	STAU1	Marion,1999
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	NXT1	Satterly,2007
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	TARBP2	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	EIF2AK2	Tan,1998
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	NXF1	Satterly,2007
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	RAE1	Satterly,2007
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	HNRPUL1	Satterly,2007
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	PIK3R2	Hale,2006
  Influenza A (A/New York/392/2004(H3N2))	NS1 Protein	Homo sapiens	PABPC1	Burgui,2003
  Influenza A (A/mallard/Netherlands/12/2000(H7N3))	NS1 Protein	Homo sapiens	CRK	Heikkinen,2008
  Influenza A (A/mallard/Netherlands/12/2000(H7N3))	NS1 Protein	Homo sapiens	CRKL	Heikkinen,2008
  Influenza A (A/WSN/1933 TS61(H1N1))	NS1 Protein	Homo sapiens	PIK3R2	Hale,2006
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	NCL	Murayama,2007
  Influenza A (A/Brevig Mission/1/1918(H1N1))	NS1 Protein	Homo sapiens	CRK	Heikkinen,2008
  Influenza A (A/Brevig Mission/1/1918(H1N1))	NS1 Protein	Homo sapiens	CRKL	Heikkinen,2008
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	KPNA1	Melen,2007
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	KPNA2	Melen,2007
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	KPNA3	Melen,2007
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	KPNA4	Melen,2007
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	KPNA5	Melen,2007
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	KPNA6	Melen,2007
  Influenza A (A/WSN/1933 TS61(H1N1))	NS1 Protein	Homo sapiens	KPNA1	Melen,2007
  Influenza A (A/WSN/1933 TS61(H1N1))	NS1 Protein	Homo sapiens	KPNA2	Melen,2007
  Influenza A (A/WSN/1933 TS61(H1N1))	NS1 Protein	Homo sapiens	KPNA3	Melen,2007
  Influenza A (A/WSN/1933 TS61(H1N1))	NS1 Protein	Homo sapiens	KPNA4	Melen,2007
  Influenza A (A/WSN/1933 TS61(H1N1))	NS1 Protein	Homo sapiens	KPNA5	Melen,2007
  Influenza A (A/WSN/1933 TS61(H1N1))	NS1 Protein	Homo sapiens	KPNA6	Melen,2007
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	DDX58	Mibayashi,2007
  Influenza A (A/lvPR8/34(H1N1))	NS1 Protein	Homo sapiens	PIK3R1	Shin,2007
  Influenza A (A/Udorn/307/1972(H3N2))	NS1 Protein	Homo sapiens	PABPN1	Chen,1999
  Influenza A (A/Udorn/307/1972(H3N2))	NS1 Protein	Homo sapiens	CPSF4	Chen,1999
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	BANP	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	FXR2	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	KHDRBS3	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	KIAA1143	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	KPNA3	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	LNX2	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	LYPLA1	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	MAPK9	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	ENSG00000146666	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	MTAP	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	PRKRA	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	SEPT1	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	SP100	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	STX5	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	UBE2I	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	ZMAT3	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	ZMAT4	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	ZNF346	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	BHLHB2	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	CCDC33	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	CPSF4	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	DOCK8	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	DVL2	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	GOLGA2	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	HMBOX1	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	KHDRBS3	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	LNX2	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	LZTS2	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	CSAG2	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	CSAG3A	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	hCG_1740678	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	MAGEA12	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	MAPK9	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	PRKRA	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	SSX2IP	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	STAU1	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	TARBP2	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	TRIM27	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	UBE2I	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	ZMAT3	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	ZMAT4	Shapira,2009
  Influenza A (A/udorn/1972(H3N2))	NS1 Protein	Homo sapiens	ZNF346	Shapira,2009
  Influenza A (A/Puerto Rico/8/34(H1N1))	NS1 Protein	Homo sapiens	TRIM25	Gack,2009

  Biological Pathways

  • Interferon signaling