Coronavirus spike

Sequence Alignments

• protein alignment JalView
• FASTA format nucleotide sequence
• FASTA format protein sequences
• FASTA format protein alignment

Structures

• SARS CoV spike PDB 3KBH, PDBsum 3KBH
• SARS CoV spike- receptor binding domain PDB 2AJF, PDBsum 2AJF
• SARS CoV spike- receptor binding domain complexed with antibody PDB 2DD8, PDBsum 2DD8
• SARS CoV spike- receptor binding domain; Crystal Structure PDB 2GHV, PDBsum 2GHV
• SARS CoV spike- receptor binding domain complexed with receptor PDB 3D0G, PDBsum 3D0G
• XtalPred cannot analyze SARS spike protein, as it has too many residues.

Domains and Families

• NCBI Conserved Domains
• PFAM

Protein-protein interactions

Virus-virus

Virus-host

• Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, PDB 1R42, Gene summary
• Eukaryotic translation initiation factor 3, subunit F, Gene summary
• Reference 1, Reference 2, Reference 3

Biological Pathways

• Renin-angiotensin system
• Angiotensin antagonists
• Neuroactive ligand-receptor interaction
• Hypertrophic cardiomyopathy (HCM)
• Dilated cardiomyopathy
• Vascular smooth muscle contraction

Other Species